General Information
Gene ID | 22943 |
---|---|
Gene Symbol | DKK1 |
Gene Name | dickkopf WNT signaling pathway inhibitor 1 |
Gene Type | protein-coding |
Cytoband | 10q11.2 |
Ensembl ID | ENSG00000107984 |
#miR regulators | 7 |
Omim ID | 605189 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000904: cell morphogenesis involved in differentiation GO:0001706: endoderm formation GO:0001707: mesoderm formation GO:0001942: hair follicle development GO:0002090: regulation of receptor internalization GO:0030326: embryonic limb morphogenesis GO:0030514: negative regulation of BMP signaling pathway GO:0030900: forebrain development GO:0031333: negative regulation of protein complex assembly GO:0032526: response to retinoic acid GO:0033137: negative regulation of peptidyl-serine phosphorylation GO:0042662: negative regulation of mesodermal cell fate specification GO:0042663: regulation of endodermal cell fate specification GO:0048642: negative regulation of skeletal muscle tissue development GO:0060325: face morphogenesis GO:0060394: negative regulation of pathway-restricted SMAD protein phosphorylation GO:0090082: positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:0090244: Wnt receptor signaling pathway involved in somitogenesis GO:1900116: extracellular negative regulation of signal transduction GO:1901296: negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment GO:2000726: negative regulation of cardiac muscle cell differentiation GO:0005886: plasma membrane GO:0005615: extracellular space GO:0005515: protein binding GO:0004871: signal transducer activity GO:0008083: growth factor activity GO:0048019: receptor antagonist activity GO:0050750: low-density lipoprotein particle receptor binding |
KEGG pathways |
4310: Wnt signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
17987039 | A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. | yes | yes |
title | all | all |