Results for DKK1

General Information

Gene ID 22943
Gene Symbol DKK1
Gene Name dickkopf WNT signaling pathway inhibitor 1
Gene Type protein-coding
Cytoband 10q11.2
Ensembl ID ENSG00000107984
#miR regulators 7
Omim ID 605189
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000904: cell morphogenesis involved in differentiation
GO:0001706: endoderm formation
GO:0001707: mesoderm formation
GO:0001942: hair follicle development
GO:0002090: regulation of receptor internalization
GO:0030326: embryonic limb morphogenesis
GO:0030514: negative regulation of BMP signaling pathway
GO:0030900: forebrain development
GO:0031333: negative regulation of protein complex assembly
GO:0032526: response to retinoic acid
GO:0033137: negative regulation of peptidyl-serine phosphorylation
GO:0042662: negative regulation of mesodermal cell fate specification
GO:0042663: regulation of endodermal cell fate specification
GO:0048642: negative regulation of skeletal muscle tissue development
GO:0060325: face morphogenesis
GO:0060394: negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0090082: positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0090244: Wnt receptor signaling pathway involved in somitogenesis
GO:1900116: extracellular negative regulation of signal transduction
GO:1901296: negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:2000726: negative regulation of cardiac muscle cell differentiation
GO:0005886: plasma membrane
GO:0005615: extracellular space
GO:0005515: protein binding
GO:0004871: signal transducer activity
GO:0008083: growth factor activity
GO:0048019: receptor antagonist activity
GO:0050750: low-density lipoprotein particle receptor binding
KEGG pathways 4310: Wnt signaling pathway

PubMed abstracts associated with DKK1

PMID Title Tumor Value
17987039 A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. yes yes
title all all