Results for FLT1

General Information

Gene ID 2321
Gene Symbol FLT1
Gene Name fms-related tyrosine kinase 1
Gene Type protein-coding
Cytoband 13q12
Ensembl ID ENSG00000102755
#miR regulators 18
Omim ID 165070
Gene ontology GO:0001569: patterning of blood vessels
GO:0002040: sprouting angiogenesis
GO:0002548: monocyte chemotaxis
GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284: positive regulation of cell proliferation
GO:0010863: positive regulation of phospholipase C activity
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0016477: cell migration
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0030154: cell differentiation
GO:0030335: positive regulation of cell migration
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0036323: vascular endothelial growth factor receptor-1 signaling pathway
GO:0043406: positive regulation of MAP kinase activity
GO:0043410: positive regulation of MAPK cascade
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766: positive regulation of angiogenesis
GO:0046777: protein autophosphorylation
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048514: blood vessel morphogenesis
GO:0048598: embryonic morphogenesis
GO:0005886: plasma membrane
GO:0005887: integral to plasma membrane
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005768: endosome
GO:0005794: Golgi apparatus
GO:0005515: protein binding
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0019838: growth factor binding
GO:0005021: vascular endothelial growth factor-activated receptor activity
GO:0005524: ATP binding
GO:0042802: identical protein binding
GO:0036326: VEGF-A-activated receptor activity
GO:0036327: VEGF-B-activated receptor activity
GO:0036332: placental growth factor-activated receptor activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4510: Focal adhesion
5323: Rheumatoid arthritis

PubMed abstracts associated with FLT1

PMID Title Tumor Value
10533453 Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. yes yes
18332870 Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. no no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
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