General Information
Gene ID | 2321 |
---|---|
Gene Symbol | FLT1 |
Gene Name | fms-related tyrosine kinase 1 |
Gene Type | protein-coding |
Cytoband | 13q12 |
Ensembl ID | ENSG00000102755 |
#miR regulators | 18 |
Omim ID | 165070 |
Gene ontology |
GO:0001569: patterning of blood vessels GO:0002040: sprouting angiogenesis GO:0002548: monocyte chemotaxis GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0008284: positive regulation of cell proliferation GO:0010863: positive regulation of phospholipase C activity GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0016477: cell migration GO:0018108: peptidyl-tyrosine phosphorylation GO:0030154: cell differentiation GO:0030335: positive regulation of cell migration GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0035924: cellular response to vascular endothelial growth factor stimulus GO:0036323: vascular endothelial growth factor receptor-1 signaling pathway GO:0043406: positive regulation of MAP kinase activity GO:0043410: positive regulation of MAPK cascade GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0045766: positive regulation of angiogenesis GO:0046777: protein autophosphorylation GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048514: blood vessel morphogenesis GO:0048598: embryonic morphogenesis GO:0005886: plasma membrane GO:0005887: integral to plasma membrane GO:0005615: extracellular space GO:0005634: nucleus GO:0005737: cytoplasm GO:0005768: endosome GO:0005794: Golgi apparatus GO:0005515: protein binding GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0019838: growth factor binding GO:0005021: vascular endothelial growth factor-activated receptor activity GO:0005524: ATP binding GO:0042802: identical protein binding GO:0036326: VEGF-A-activated receptor activity GO:0036327: VEGF-B-activated receptor activity GO:0036332: placental growth factor-activated receptor activity |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4144: Endocytosis 4510: Focal adhesion 5323: Rheumatoid arthritis |
PMID | Title | Tumor | Value |
---|---|---|---|
10533453 | Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. | yes | yes |
18332870 | Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. | no | no |
21240382 | Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. | yes | yes |
title | all | all |