Results for FLT3

General Information

Gene ID 2322
Gene Symbol FLT3
Gene Name fms-related tyrosine kinase 3
Gene Type protein-coding
Cytoband 13q12
Ensembl ID ENSG00000122025
#miR regulators 10
Omim ID 136351 601626
Gene ontology GO:0001776: leukocyte homeostasis
GO:0002318: myeloid progenitor cell differentiation
GO:0002328: pro-B cell differentiation
GO:0002572: pro-T cell differentiation
GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0042981: regulation of apoptotic process
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019221: cytokine-mediated signaling pathway
GO:0030097: hemopoiesis
GO:0030183: B cell differentiation
GO:0035726: common myeloid progenitor cell proliferation
GO:0038084: vascular endothelial growth factor signaling pathway
GO:0042531: positive regulation of tyrosine phosphorylation of STAT protein
GO:0043406: positive regulation of MAP kinase activity
GO:0043410: positive regulation of MAPK cascade
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045578: negative regulation of B cell differentiation
GO:0046651: lymphocyte proliferation
GO:0046777: protein autophosphorylation
GO:0071345: cellular response to cytokine stimulus
GO:0097028: dendritic cell differentiation
GO:0005887: integral to plasma membrane
GO:0005788: endoplasmic reticulum lumen
GO:0009986: cell surface
GO:0005515: protein binding
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0004896: cytokine receptor activity
GO:0005021: vascular endothelial growth factor-activated receptor activity
GO:0005524: ATP binding
GO:0042803: protein homodimerization activity
GO:0043548: phosphatidylinositol 3-kinase binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4640: Hematopoietic cell lineage
5200: Pathways in cancer
5221: Acute myeloid leukemia

PubMed abstracts associated with FLT3

PMID Title Tumor Value
22422053 Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. no no
title all all