General Information
Gene ID | 2324 |
---|---|
Gene Symbol | FLT4 |
Gene Name | fms-related tyrosine kinase 4 |
Gene Type | protein-coding |
Cytoband | 5q35.3 |
Ensembl ID | ENSG00000037280 |
#miR regulators | 6 |
Omim ID | 136352 153100 |
Gene ontology |
GO:0001934: positive regulation of protein phosphorylation GO:0001938: positive regulation of endothelial cell proliferation GO:0001944: vasculature development GO:0001945: lymph vessel development GO:0001946: lymphangiogenesis GO:0002040: sprouting angiogenesis GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0010575: positive regulation vascular endothelial growth factor production GO:0010595: positive regulation of endothelial cell migration GO:0018108: peptidyl-tyrosine phosphorylation GO:0035924: cellular response to vascular endothelial growth factor stimulus GO:0043410: positive regulation of MAPK cascade GO:0046330: positive regulation of JNK cascade GO:0046777: protein autophosphorylation GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048514: blood vessel morphogenesis GO:0060312: regulation of blood vessel remodeling GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0090037: positive regulation of protein kinase C signaling cascade GO:0005886: plasma membrane GO:0005576: extracellular region GO:0005887: integral to plasma membrane GO:0005634: nucleus GO:0005737: cytoplasm GO:0005515: protein binding GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0019838: growth factor binding GO:0005021: vascular endothelial growth factor-activated receptor activity GO:0005524: ATP binding GO:0019903: protein phosphatase binding |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4510: Focal adhesion |
PMID | Title | Tumor | Value |
---|---|---|---|
18438338 | VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. | yes | no |
19670450 | Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. | yes | no |
21751203 | Cell surface receptor expression patterns in osteosarcoma. | yes | no |
title | all | all |