Results for FLT4

General Information

Gene ID 2324
Gene Symbol FLT4
Gene Name fms-related tyrosine kinase 4
Gene Type protein-coding
Cytoband 5q35.3
Ensembl ID ENSG00000037280
#miR regulators 6
Omim ID 136352 153100
Gene ontology GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0001944: vasculature development
GO:0001945: lymph vessel development
GO:0001946: lymphangiogenesis
GO:0002040: sprouting angiogenesis
GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0010595: positive regulation of endothelial cell migration
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0043410: positive regulation of MAPK cascade
GO:0046330: positive regulation of JNK cascade
GO:0046777: protein autophosphorylation
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048514: blood vessel morphogenesis
GO:0060312: regulation of blood vessel remodeling
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0090037: positive regulation of protein kinase C signaling cascade
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005515: protein binding
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0019838: growth factor binding
GO:0005021: vascular endothelial growth factor-activated receptor activity
GO:0005524: ATP binding
GO:0019903: protein phosphatase binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4510: Focal adhesion

PubMed abstracts associated with FLT4

PMID Title Tumor Value
18438338 VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. yes no
19670450 Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. yes no
21751203 Cell surface receptor expression patterns in osteosarcoma. yes no
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