General Information
| Gene ID | 2335 |
|---|---|
| Gene Symbol | FN1 |
| Gene Name | fibronectin 1 |
| Gene Type | protein-coding |
| Cytoband | 2q34 |
| Ensembl ID | ENSG00000115414 |
| #miR regulators | 13 |
| Omim ID | 135600 601894 614101 |
| Gene ontology |
GO:0001525: angiogenesis GO:0002576: platelet degranulation GO:0006953: acute-phase response GO:0007596: blood coagulation GO:0007155: cell adhesion GO:0007044: cell-substrate junction assembly GO:0007161: calcium-independent cell-matrix adhesion GO:0008360: regulation of cell shape GO:0009611: response to wounding GO:0016477: cell migration GO:0018149: peptide cross-linking GO:0030168: platelet activation GO:0030198: extracellular matrix organization GO:0034446: substrate adhesion-dependent cell spreading GO:0050900: leukocyte migration GO:0005576: extracellular region GO:0005577: fibrinogen complex GO:0005578: proteinaceous extracellular matrix GO:0005604: basement membrane GO:0005615: extracellular space GO:0005793: endoplasmic reticulum-Golgi intermediate compartment GO:0016324: apical plasma membrane GO:0031012: extracellular matrix GO:0031093: platelet alpha granule lumen GO:0005515: protein binding GO:0005201: extracellular matrix structural constituent GO:0005518: collagen binding GO:0008201: heparin binding GO:0016504: peptidase activator activity |
| KEGG pathways |
4510: Focal adhesion 4512: ECM-receptor interaction 4810: Regulation of actin cytoskeleton 5100: Bacterial invasion of epithelial cells 5146: Amoebiasis 5200: Pathways in cancer 5222: Small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 2443508 | Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. | no | no |
| 2521862 | Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. | no | no |
| 8159609 | Extracellular matrix of small round cell tumors of childhood: an immunohistochemical study of 67 cases. | yes | yes |
| 8166715 | Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. | no | no |
| 11156738 | Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. | no | no |
| 12232677 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. | no | no |
| 12930359 | IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. | no | no |
| 15746965 | Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. | no | no |
| 16798617 | Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. | no | no |
| 17318900 | Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. | no | no |
| 18093185 | Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells. | no | no |
| 18445685 | PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. | yes | no |
| 21421073 | Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity. | no | no |
| 22531343 | Syndecan-4 and fibronectin in osteosarcoma. | yes | yes |
| title | all | all |