Results for FN1

General Information

Gene ID 2335
Gene Symbol FN1
Gene Name fibronectin 1
Gene Type protein-coding
Cytoband 2q34
Ensembl ID ENSG00000115414
#miR regulators 13
Omim ID 135600 601894 614101
Gene ontology GO:0001525: angiogenesis
GO:0002576: platelet degranulation
GO:0006953: acute-phase response
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007044: cell-substrate junction assembly
GO:0007161: calcium-independent cell-matrix adhesion
GO:0008360: regulation of cell shape
GO:0009611: response to wounding
GO:0016477: cell migration
GO:0018149: peptide cross-linking
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0034446: substrate adhesion-dependent cell spreading
GO:0050900: leukocyte migration
GO:0005576: extracellular region
GO:0005577: fibrinogen complex
GO:0005578: proteinaceous extracellular matrix
GO:0005604: basement membrane
GO:0005615: extracellular space
GO:0005793: endoplasmic reticulum-Golgi intermediate compartment
GO:0016324: apical plasma membrane
GO:0031012: extracellular matrix
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0005201: extracellular matrix structural constituent
GO:0005518: collagen binding
GO:0008201: heparin binding
GO:0016504: peptidase activator activity
KEGG pathways 4510: Focal adhesion
4512: ECM-receptor interaction
4810: Regulation of actin cytoskeleton
5100: Bacterial invasion of epithelial cells
5146: Amoebiasis
5200: Pathways in cancer
5222: Small cell lung cancer

PubMed abstracts associated with FN1

PMID Title Tumor Value
2443508 Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. no no
2521862 Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. no no
8159609 Extracellular matrix of small round cell tumors of childhood: an immunohistochemical study of 67 cases. yes yes
8166715 Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. no no
11156738 Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. no no
12232677 Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. no no
12930359 IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. no no
15746965 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. no no
16798617 Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. no no
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
18093185 Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells. no no
18445685 PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. yes no
21421073 Lumican regulates osteosarcoma cell adhesion by modulating TGF?2 activity. no no
22531343 Syndecan-4 and fibronectin in osteosarcoma. yes yes
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