Results for FOS

General Information

Gene ID 2353
Gene Symbol FOS
Gene Name FBJ murine osteosarcoma viral oncogene homolog
Gene Type protein-coding
Cytoband 14q24.3
Ensembl ID ENSG00000170345
#miR regulators 8
Omim ID 164810
Gene ontology GO:0001661: conditioned taste aversion
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006366: transcription from RNA polymerase II promoter
GO:0006306: DNA methylation
GO:0006357: regulation of transcription from RNA polymerase II promoter
GO:0009612: response to mechanical stimulus
GO:0006954: inflammatory response
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007399: nervous system development
GO:0007565: female pregnancy
GO:0007568: aging
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0009409: response to cold
GO:0009416: response to light stimulus
GO:0009629: response to gravity
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0030431: sleep
GO:0031668: cellular response to extracellular stimulus
GO:0032496: response to lipopolysaccharide
GO:0032570: response to progesterone stimulus
GO:0032870: cellular response to hormone stimulus
GO:0034097: response to cytokine stimulus
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0034614: cellular response to reactive oxygen species
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0035914: skeletal muscle cell differentiation
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087: innate immune response
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0051090: regulation of sequence-specific DNA binding transcription factor activity
GO:0051403: stress-activated MAPK cascade
GO:0051412: response to corticosterone stimulus
GO:0051591: response to cAMP
GO:0060395: SMAD protein signal transduction
GO:0071277: cellular response to calcium ion
GO:0016020: membrane
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0043005: neuron projection
GO:0005515: protein binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0043565: sequence-specific DNA binding
GO:0070412: R-SMAD binding
KEGG pathways 4010: MAPK signaling pathway
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5200: Pathways in cancer
5210: Colorectal cancer
5323: Rheumatoid arthritis

PubMed abstracts associated with FOS

PMID Title Tumor Value
1846564 Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. no no
2115647 The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas. yes no
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no
8099316 Overexpression of c-fos increases recombination frequency in human osteosarcoma cells. no no
8891902 Oncogene alterations in primary, recurrent, and metastatic human bone tumors. yes yes
9258335 Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. no no
9443071 Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. no no
9672192 Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton. yes yes
9778623 C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression. yes yes
11115584 Osteosarcoma in blood relatives. yes no
11398843 Detection of c-fos expression in benign and malignant musculoskeletal lesions. yes no
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no
12689679 Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. yes yes
14682477 Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
21801875 Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. yes no
22855059 Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. yes yes
22939995 IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. yes no
23219526 Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. no no
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