Results for MTOR

General Information

Gene ID 2475
Gene Symbol MTOR
Gene Name mechanistic target of rapamycin (serine/threonine kinase)
Gene Type protein-coding
Cytoband 1p36.2
Ensembl ID ENSG00000198793
#miR regulators 3
Omim ID 601231
Gene ontology GO:0016049: cell growth
GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0007165: signal transduction
GO:0005979: regulation of glycogen biosynthetic process
GO:0006468: protein phosphorylation
GO:0006950: response to stress
GO:0040007: growth
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007281: germ cell development
GO:0007584: response to nutrient
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010507: negative regulation of autophagy
GO:0010592: positive regulation of lamellipodium assembly
GO:0010628: positive regulation of gene expression
GO:0010831: positive regulation of myotube differentiation
GO:0045727: positive regulation of translation
GO:0046889: positive regulation of lipid biosynthetic process
GO:0016242: negative regulation of macroautophagy
GO:0016310: phosphorylation
GO:0018105: peptidyl-serine phosphorylation
GO:0018107: peptidyl-threonine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030163: protein catabolic process
GO:0030838: positive regulation of actin filament polymerization
GO:0031295: T cell costimulation
GO:0031529: ruffle organization
GO:0031669: cellular response to nutrient levels
GO:0031929: TOR signaling cascade
GO:0031998: regulation of fatty acid beta-oxidation
GO:0032095: regulation of response to food
GO:0032314: regulation of Rac GTPase activity
GO:0032956: regulation of actin cytoskeleton organization
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0043200: response to amino acid stimulus
GO:0043610: regulation of carbohydrate utilization
GO:0045087: innate immune response
GO:0045792: negative regulation of cell size
GO:0045859: regulation of protein kinase activity
GO:0045945: positive regulation of transcription from RNA polymerase III promoter
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0051496: positive regulation of stress fiber assembly
GO:0051534: negative regulation of NFAT protein import into nucleus
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0071456: cellular response to hypoxia
GO:0000139: Golgi membrane
GO:0016020: membrane
GO:0005764: lysosome
GO:0005829: cytosol
GO:0005737: cytoplasm
GO:0005741: mitochondrial outer membrane
GO:0005789: endoplasmic reticulum membrane
GO:0005942: phosphatidylinositol 3-kinase complex
GO:0012505: endomembrane system
GO:0016605: PML body
GO:0031931: TORC1 complex
GO:0031932: TORC2 complex
GO:0070438: mTOR-FKBP12-rapamycin complex
GO:0005515: protein binding
GO:0001030: RNA polymerase III type 1 promoter DNA binding
GO:0001031: RNA polymerase III type 2 promoter DNA binding
GO:0001032: RNA polymerase III type 3 promoter DNA binding
GO:0001156: TFIIIC-class transcription factor binding
GO:0004674: protein serine/threonine kinase activity
GO:0005524: ATP binding
GO:0008144: drug binding
GO:0016301: kinase activity
GO:0019904: protein domain specific binding
GO:0043022: ribosome binding
GO:0051219: phosphoprotein binding
KEGG pathways 4012: ErbB signaling pathway
4150: mTOR signaling pathway
4910: Insulin signaling pathway
4920: Adipocytokine signaling pathway
4930: Type II diabetes mellitus
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5221: Acute myeloid leukemia

PubMed abstracts associated with MTOR

PMID Title Tumor Value
19148492 Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. no no
19936974 mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. yes yes
21246613 Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. no no
21440986 Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. no no
21666078 MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. yes no
22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways. no no
23208072 Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. no no
23879172 FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. no no
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