General Information
Gene ID | 2475 |
---|---|
Gene Symbol | MTOR |
Gene Name | mechanistic target of rapamycin (serine/threonine kinase) |
Gene Type | protein-coding |
Cytoband | 1p36.2 |
Ensembl ID | ENSG00000198793 |
#miR regulators | 3 |
Omim ID | 601231 |
Gene ontology |
GO:0016049: cell growth GO:0001934: positive regulation of protein phosphorylation GO:0001938: positive regulation of endothelial cell proliferation GO:0007165: signal transduction GO:0005979: regulation of glycogen biosynthetic process GO:0006468: protein phosphorylation GO:0006950: response to stress GO:0040007: growth GO:0007173: epidermal growth factor receptor signaling pathway GO:0007281: germ cell development GO:0007584: response to nutrient GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0010507: negative regulation of autophagy GO:0010592: positive regulation of lamellipodium assembly GO:0010628: positive regulation of gene expression GO:0010831: positive regulation of myotube differentiation GO:0045727: positive regulation of translation GO:0046889: positive regulation of lipid biosynthetic process GO:0016242: negative regulation of macroautophagy GO:0016310: phosphorylation GO:0018105: peptidyl-serine phosphorylation GO:0018107: peptidyl-threonine phosphorylation GO:0048015: phosphatidylinositol-mediated signaling GO:0030163: protein catabolic process GO:0030838: positive regulation of actin filament polymerization GO:0031295: T cell costimulation GO:0031529: ruffle organization GO:0031669: cellular response to nutrient levels GO:0031929: TOR signaling cascade GO:0031998: regulation of fatty acid beta-oxidation GO:0032095: regulation of response to food GO:0032314: regulation of Rac GTPase activity GO:0032956: regulation of actin cytoskeleton organization GO:0038095: Fc-epsilon receptor signaling pathway GO:0043200: response to amino acid stimulus GO:0043610: regulation of carbohydrate utilization GO:0045087: innate immune response GO:0045792: negative regulation of cell size GO:0045859: regulation of protein kinase activity GO:0045945: positive regulation of transcription from RNA polymerase III promoter GO:0046777: protein autophosphorylation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0051496: positive regulation of stress fiber assembly GO:0051534: negative regulation of NFAT protein import into nucleus GO:0051897: positive regulation of protein kinase B signaling cascade GO:0071456: cellular response to hypoxia GO:0000139: Golgi membrane GO:0016020: membrane GO:0005764: lysosome GO:0005829: cytosol GO:0005737: cytoplasm GO:0005741: mitochondrial outer membrane GO:0005789: endoplasmic reticulum membrane GO:0005942: phosphatidylinositol 3-kinase complex GO:0012505: endomembrane system GO:0016605: PML body GO:0031931: TORC1 complex GO:0031932: TORC2 complex GO:0070438: mTOR-FKBP12-rapamycin complex GO:0005515: protein binding GO:0001030: RNA polymerase III type 1 promoter DNA binding GO:0001031: RNA polymerase III type 2 promoter DNA binding GO:0001032: RNA polymerase III type 3 promoter DNA binding GO:0001156: TFIIIC-class transcription factor binding GO:0004674: protein serine/threonine kinase activity GO:0005524: ATP binding GO:0008144: drug binding GO:0016301: kinase activity GO:0019904: protein domain specific binding GO:0043022: ribosome binding GO:0051219: phosphoprotein binding |
KEGG pathways |
4012: ErbB signaling pathway 4150: mTOR signaling pathway 4910: Insulin signaling pathway 4920: Adipocytokine signaling pathway 4930: Type II diabetes mellitus 5200: Pathways in cancer 5214: Glioma 5215: Prostate cancer 5221: Acute myeloid leukemia |
PMID | Title | Tumor | Value |
---|---|---|---|
19148492 | Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. | no | no |
19936974 | mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. | yes | yes |
21246613 | Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. | no | no |
21440986 | Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. | no | no |
21666078 | MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. | yes | no |
22993301 | Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. | no | no |
23208072 | Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. | no | no |
23879172 | FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. | no | no |
title | all | all |