General Information
| Gene ID | 249 |
|---|---|
| Gene Symbol | ALPL |
| Gene Name | alkaline phosphatase, liver/bone/kidney |
| Gene Type | protein-coding |
| Cytoband | 1p36.12 |
| Ensembl ID | ENSG00000162551 |
| #miR regulators | 1 |
| Omim ID | 146300 171760 241500 241510 |
| Gene ontology |
GO:0001501: skeletal system development GO:0001958: endochondral ossification GO:0003006: developmental process involved in reproduction GO:0046677: response to antibiotic GO:0032496: response to lipopolysaccharide GO:0033280: response to vitamin D GO:0051384: response to glucocorticoid stimulus GO:0071407: cellular response to organic cyclic compound GO:0071529: cementum mineralization GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005615: extracellular space GO:0031225: anchored to membrane GO:0004035: alkaline phosphatase activity GO:0046872: metal ion binding GO:0016462: pyrophosphatase activity |
| KEGG pathways |
790: Folate biosynthesis 1100: Metabolic pathways |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 292511 | Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. | yes | yes |
| 1499384 | The prognostic value of serum alkaline phosphatase in osteosarcoma of the limbs. | yes | yes |
| 1525710 | A phorbol ester induces secretion of alkaline phosphatase activity in human osteosarcoma cells. | no | no |
| 2521862 | Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. | no | no |
| 2786815 | Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. | no | no |
| 3166362 | Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin. | no | no |
| 3477902 | Prognostic value of serum alkaline phosphatase in osteosarcoma. | yes | yes |
| 6297258 | Enzyme histochemical study on bone tumors. | yes | no |
| 6930152 | Correlation between prognostic factors and blood variables in osteosarcoma. | yes | no |
| 7576109 | Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. | no | no |
| 7794813 | Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. | no | no |
| 7912235 | Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. | no | no |
| 8435797 | Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy. | yes | yes |
| 8692530 | Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma. | yes | yes |
| 8726395 | Immunohistochemical localization of the estrogen receptor in human osteoblastic SaOS-2 cells: association of receptor levels with alkaline phosphatase activity. | no | no |
| 8992882 | Constitutive expression of non-bone/liver/kidney alkaline phosphatase in human osteosarcoma cell lines. | no | yes |
| 9167046 | Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. | yes | no |
| 10709992 | Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. | no | no |
| 10773107 | Steroid receptor co-activator-1 mediates 1,25-dihydroxyvitamin D(3)-stimulated alkaline phosphatase in human osteosarcoma cells. | no | no |
| 11306692 | The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. | no | no |
| 12054686 | Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. | no | no |
| 12188489 | Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. | yes | yes |
| 12232677 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. | no | no |
| 12672477 | Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. | no | no |
| 15670817 | Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. | no | no |
| 15742288 | Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. | no | no |
| 15946696 | Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. | no | no |
| 16007340 | Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. | no | no |
| 16259979 | Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. | no | no |
| 16533764 | Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. | no | no |
| 16933368 | Effects of hyperthermia on heat shock protein expression, alkaline phosphatase activity and proliferation in human osteosarcoma cells. | no | no |
| 16956425 | Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. | no | no |
| 17120184 | Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. | no | no |
| 17189270 | alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. | no | no |
| 17458711 | Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. | no | no |
| 18374478 | Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin. | no | no |
| 18838962 | Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. | no | no |
| 19746447 | Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. | no | no |
| 19882675 | Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. | yes | no |
| 20627196 | Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. | no | no |
| 21084254 | Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. | yes | yes |
| 22126551 | Relationships between serum biomarker levels and clinical presentation of human osteosarcomas. | yes | no |
| 22333159 | High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. | yes | yes |
| 22527131 | Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. | no | no |
| title | all | all |