Results for ALPL

General Information

Gene ID 249
Gene Symbol ALPL
Gene Name alkaline phosphatase, liver/bone/kidney
Gene Type protein-coding
Cytoband 1p36.12
Ensembl ID ENSG00000162551
#miR regulators 1
Omim ID 146300 171760 241500 241510
Gene ontology GO:0001501: skeletal system development
GO:0001958: endochondral ossification
GO:0003006: developmental process involved in reproduction
GO:0046677: response to antibiotic
GO:0032496: response to lipopolysaccharide
GO:0033280: response to vitamin D
GO:0051384: response to glucocorticoid stimulus
GO:0071407: cellular response to organic cyclic compound
GO:0071529: cementum mineralization
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005615: extracellular space
GO:0031225: anchored to membrane
GO:0004035: alkaline phosphatase activity
GO:0046872: metal ion binding
GO:0016462: pyrophosphatase activity
KEGG pathways 790: Folate biosynthesis
1100: Metabolic pathways

PubMed abstracts associated with ALPL

PMID Title Tumor Value
292511 Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. yes yes
1499384 The prognostic value of serum alkaline phosphatase in osteosarcoma of the limbs. yes yes
1525710 A phorbol ester induces secretion of alkaline phosphatase activity in human osteosarcoma cells. no no
2521862 Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. no no
2786815 Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. no no
3166362 Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin. no no
3477902 Prognostic value of serum alkaline phosphatase in osteosarcoma. yes yes
6297258 Enzyme histochemical study on bone tumors. yes no
6930152 Correlation between prognostic factors and blood variables in osteosarcoma. yes no
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no
7794813 Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. no no
7912235 Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. no no
8435797 Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy. yes yes
8692530 Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma. yes yes
8726395 Immunohistochemical localization of the estrogen receptor in human osteoblastic SaOS-2 cells: association of receptor levels with alkaline phosphatase activity. no no
8992882 Constitutive expression of non-bone/liver/kidney alkaline phosphatase in human osteosarcoma cell lines. no yes
9167046 Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. yes no
10709992 Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. no no
10773107 Steroid receptor co-activator-1 mediates 1,25-dihydroxyvitamin D(3)-stimulated alkaline phosphatase in human osteosarcoma cells. no no
11306692 The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. no no
12054686 Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. no no
12188489 Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. yes yes
12232677 Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. no no
12672477 Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
15742288 Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. no no
15946696 Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. no no
16007340 Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. no no
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no
16533764 Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. no no
16933368 Effects of hyperthermia on heat shock protein expression, alkaline phosphatase activity and proliferation in human osteosarcoma cells. no no
16956425 Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. no no
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no
17189270 alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. no no
17458711 Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. no no
18374478 Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin. no no
18838962 Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. no no
19746447 Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. no no
19882675 Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. yes no
20627196 Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. no no
21084254 Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. yes yes
22126551 Relationships between serum biomarker levels and clinical presentation of human osteosarcomas. yes no
22333159 High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. yes yes
22527131 Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. no no
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