Results for ABL1

General Information

Gene ID 25
Gene Symbol ABL1
Gene Name c-abl oncogene 1, non-receptor tyrosine kinase
Gene Type protein-coding
Cytoband 9q34.1
Ensembl ID ENSG00000097007
#miR regulators 8
Omim ID 189980
Gene ontology GO:0000115: regulation of transcription involved in S phase of mitotic cell cycle
GO:0051726: regulation of cell cycle
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0006298: mismatch repair
GO:0006355: regulation of transcription, DNA-dependent
GO:0006464: cellular protein modification process
GO:0006914: autophagy
GO:0006974: response to DNA damage stimulus
GO:0006975: DNA damage induced protein phosphorylation
GO:0007411: axon guidance
GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010506: regulation of autophagy
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0030100: regulation of endocytosis
GO:0030155: regulation of cell adhesion
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042692: muscle cell differentiation
GO:0042770: signal transduction in response to DNA damage
GO:0043065: positive regulation of apoptotic process
GO:0045087: innate immune response
GO:0048008: platelet-derived growth factor receptor signaling pathway
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0051149: positive regulation of muscle cell differentiation
GO:0051353: positive regulation of oxidoreductase activity
GO:0071901: negative regulation of protein serine/threonine kinase activity
GO:2000145: regulation of cell motility
GO:2000249: regulation of actin cytoskeleton reorganization
GO:2001020: regulation of response to DNA damage stimulus
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005730: nucleolus
GO:0015629: actin cytoskeleton
GO:0031252: cell leading edge
GO:0031965: nuclear membrane
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0000287: magnesium ion binding
GO:0003677: DNA binding
GO:0003785: actin monomer binding
GO:0004515: nicotinate-nucleotide adenylyltransferase activity
GO:0004713: protein tyrosine kinase activity
GO:0004715: non-membrane spanning protein tyrosine kinase activity
GO:0051019: mitogen-activated protein kinase binding
GO:0005524: ATP binding
GO:0008022: protein C-terminus binding
GO:0017124: SH3 domain binding
GO:0019905: syntaxin binding
GO:0030145: manganese ion binding
GO:0070064: proline-rich region binding
KEGG pathways 4012: ErbB signaling pathway
4110: Cell cycle
4360: Axon guidance
4722: Neurotrophin signaling pathway
5130: Pathogenic Escherichia coli infection
5131: Shigellosis
5200: Pathways in cancer
5220: Chronic myeloid leukemia
5416: Viral myocarditis

PubMed abstracts associated with ABL1

PMID Title Tumor Value
20970221 2-Hydroxypropyl-?-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. no no
title all all