General Information
Gene ID | 2658 |
---|---|
Gene Symbol | GDF2 |
Gene Name | growth differentiation factor 2 |
Gene Type | protein-coding |
Cytoband | 10q11.22 |
Ensembl ID | ENSG00000128802 ENSG00000263761 |
#miR regulators | 3 |
Omim ID | 605120 |
Gene ontology |
GO:0001503: ossification GO:0001569: patterning of blood vessels GO:0001570: vasculogenesis GO:0001649: osteoblast differentiation GO:0001937: negative regulation of endothelial cell proliferation GO:0001938: positive regulation of endothelial cell proliferation GO:0006879: cellular iron ion homeostasis GO:0040007: growth GO:0008156: negative regulation of DNA replication GO:0010596: negative regulation of endothelial cell migration GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation GO:0016525: negative regulation of angiogenesis GO:0045893: positive regulation of transcription, DNA-dependent GO:0030308: negative regulation of cell growth GO:0030509: BMP signaling pathway GO:0030513: positive regulation of BMP signaling pathway GO:0032757: positive regulation of interleukin-8 production GO:0032924: activin receptor signaling pathway GO:0043537: negative regulation of blood vessel endothelial cell migration GO:0045603: positive regulation of endothelial cell differentiation GO:0045669: positive regulation of osteoblast differentiation GO:0045766: positive regulation of angiogenesis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048514: blood vessel morphogenesis GO:0051216: cartilage development GO:0060389: pathway-restricted SMAD protein phosphorylation GO:2000279: negative regulation of DNA biosynthetic process GO:0005615: extracellular space GO:0005515: protein binding GO:0005125: cytokine activity GO:0008083: growth factor activity |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
22948234 | Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. | no | no |
23262982 | Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. | no | no |
title | all | all |