Results for GJA1

General Information

Gene ID 2697
Gene Symbol GJA1
Gene Name gap junction protein, alpha 1, 43kDa
Gene Type protein-coding
Cytoband 6q22.31
Ensembl ID ENSG00000152661
#miR regulators 16
Omim ID 121014 164200 186100 218400 241550 257850 600309
Gene ontology GO:0001649: osteoblast differentiation
GO:0001701: in utero embryonic development
GO:0001764: neuron migration
GO:0001947: heart looping
GO:0002070: epithelial cell maturation
GO:0002088: lens development in camera-type eye
GO:0003294: atrial ventricular junction remodeling
GO:0006936: muscle contraction
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006810: transport
GO:0007267: cell-cell signaling
GO:0007507: heart development
GO:0007512: adult heart development
GO:0008285: negative regulation of cell proliferation
GO:0009268: response to pH
GO:0010232: vascular transport
GO:0010628: positive regulation of gene expression
GO:0010629: negative regulation of gene expression
GO:0010643: cell communication by chemical coupling
GO:0010644: cell communication by electrical coupling
GO:0015867: ATP transport
GO:0016044: cellular membrane organization
GO:0016264: gap junction assembly
GO:0030500: regulation of bone mineralization
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043403: skeletal muscle tissue regeneration
GO:0043434: response to peptide hormone stimulus
GO:0045732: positive regulation of protein catabolic process
GO:0045844: positive regulation of striated muscle tissue development
GO:0046850: regulation of bone remodeling
GO:0048514: blood vessel morphogenesis
GO:0048812: neuron projection morphogenesis
GO:0051259: protein oligomerization
GO:0051924: regulation of calcium ion transport
GO:0060156: milk ejection
GO:0060174: limb bud formation
GO:0060307: regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371: regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373: regulation of ventricular cardiac muscle cell membrane depolarization
GO:0086014: regulation of atrial cardiac muscle cell action potential
GO:2000810: regulation of tight junction assembly
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0005882: intermediate filament
GO:0043292: contractile fiber
GO:0005764: lysosome
GO:0005829: cytosol
GO:0005887: integral to plasma membrane
GO:0005741: mitochondrial outer membrane
GO:0005769: early endosome
GO:0005771: multivesicular body
GO:0005789: endoplasmic reticulum membrane
GO:0005794: Golgi apparatus
GO:0005916: fascia adherens
GO:0005921: gap junction
GO:0005922: connexon complex
GO:0014704: intercalated disc
GO:0016324: apical plasma membrane
GO:0016328: lateral plasma membrane
GO:0030660: Golgi-associated vesicle membrane
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0005102: receptor binding
GO:0004871: signal transducer activity
GO:0005243: gap junction channel activity
GO:0015075: ion transmembrane transporter activity
GO:0017124: SH3 domain binding
GO:0030165: PDZ domain binding
GO:0048487: beta-tubulin binding
GO:0097110: scaffold protein binding
KEGG pathways 4540: Gap junction
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)

PubMed abstracts associated with GJA1

PMID Title Tumor Value
11464280 Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. no no
17343982 Negative growth control of osteosarcoma cell by Bowman-Birk protease inhibitor from soybean; involvement of connexin 43. no no
21665377 Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation. no no
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