General Information
Gene ID | 2729 |
---|---|
Gene Symbol | GCLC |
Gene Name | glutamate-cysteine ligase, catalytic subunit |
Gene Type | protein-coding |
Cytoband | 6p12 |
Ensembl ID | ENSG00000001084 |
#miR regulators | 16 |
Omim ID | 230450 606857 608446 |
Gene ontology |
GO:0000096: sulfur amino acid metabolic process GO:0045454: cell redox homeostasis GO:0006534: cysteine metabolic process GO:0006536: glutamate metabolic process GO:0006750: glutathione biosynthetic process GO:0006805: xenobiotic metabolic process GO:0006979: response to oxidative stress GO:0043066: negative regulation of apoptotic process GO:0009408: response to heat GO:0009725: response to hormone stimulus GO:0045892: negative regulation of transcription, DNA-dependent GO:0046685: response to arsenic-containing substance GO:0019852: L-ascorbic acid metabolic process GO:0031397: negative regulation of protein ubiquitination GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0034641: cellular nitrogen compound metabolic process GO:0043524: negative regulation of neuron apoptotic process GO:0044281: small molecule metabolic process GO:0050880: regulation of blood vessel size GO:0051409: response to nitrosative stress GO:0051900: regulation of mitochondrial depolarization GO:1901687: glutathione derivative biosynthetic process GO:0005829: cytosol GO:0005737: cytoplasm GO:0017109: glutamate-cysteine ligase complex GO:0000287: magnesium ion binding GO:0004357: glutamate-cysteine ligase activity GO:0005524: ATP binding GO:0016595: glutamate binding GO:0043531: ADP binding GO:0046982: protein heterodimerization activity GO:0050662: coenzyme binding |
KEGG pathways |
480: Glutathione metabolism 1100: Metabolic pathways |
PMID | Title | Tumor | Value |
---|---|---|---|
23052169 | Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas. | yes | no |
title | all | all |