Results for GCLC

General Information

Gene ID 2729
Gene Symbol GCLC
Gene Name glutamate-cysteine ligase, catalytic subunit
Gene Type protein-coding
Cytoband 6p12
Ensembl ID ENSG00000001084
#miR regulators 16
Omim ID 230450 606857 608446
Gene ontology GO:0000096: sulfur amino acid metabolic process
GO:0045454: cell redox homeostasis
GO:0006534: cysteine metabolic process
GO:0006536: glutamate metabolic process
GO:0006750: glutathione biosynthetic process
GO:0006805: xenobiotic metabolic process
GO:0006979: response to oxidative stress
GO:0043066: negative regulation of apoptotic process
GO:0009408: response to heat
GO:0009725: response to hormone stimulus
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0046685: response to arsenic-containing substance
GO:0019852: L-ascorbic acid metabolic process
GO:0031397: negative regulation of protein ubiquitination
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034641: cellular nitrogen compound metabolic process
GO:0043524: negative regulation of neuron apoptotic process
GO:0044281: small molecule metabolic process
GO:0050880: regulation of blood vessel size
GO:0051409: response to nitrosative stress
GO:0051900: regulation of mitochondrial depolarization
GO:1901687: glutathione derivative biosynthetic process
GO:0005829: cytosol
GO:0005737: cytoplasm
GO:0017109: glutamate-cysteine ligase complex
GO:0000287: magnesium ion binding
GO:0004357: glutamate-cysteine ligase activity
GO:0005524: ATP binding
GO:0016595: glutamate binding
GO:0043531: ADP binding
GO:0046982: protein heterodimerization activity
GO:0050662: coenzyme binding
KEGG pathways 480: Glutathione metabolism
1100: Metabolic pathways

PubMed abstracts associated with GCLC

PMID Title Tumor Value
23052169 Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas. yes no
title all all