Results for GLI2

General Information

Gene ID 2736
Gene Symbol GLI2
Gene Name GLI family zinc finger 2
Gene Type protein-coding
Cytoband 2q14
Ensembl ID ENSG00000074047
#miR regulators 8
Omim ID 165230 610829
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001501: skeletal system development
GO:0001649: osteoblast differentiation
GO:0001701: in utero embryonic development
GO:0001822: kidney development
GO:0002076: osteoblast development
GO:0006915: apoptotic process
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0009612: response to mechanical stimulus
GO:0007224: smoothened signaling pathway
GO:0007389: pattern specification process
GO:0007411: axon guidance
GO:0007418: ventral midline development
GO:0007442: hindgut morphogenesis
GO:0007507: heart development
GO:0008283: cell proliferation
GO:0008589: regulation of smoothened signaling pathway
GO:0009913: epidermal cell differentiation
GO:0009954: proximal/distal pattern formation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0021508: floor plate formation
GO:0021513: spinal cord dorsal/ventral patterning
GO:0021517: ventral spinal cord development
GO:0021696: cerebellar cortex morphogenesis
GO:0021775: smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021938: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021965: spinal cord ventral commissure morphogenesis
GO:0021983: pituitary gland development
GO:0030324: lung development
GO:0030879: mammary gland development
GO:0030902: hindbrain development
GO:0032331: negative regulation of chondrocyte differentiation
GO:0033089: positive regulation of T cell differentiation in thymus
GO:0035295: tube development
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042733: embryonic digit morphogenesis
GO:0045666: positive regulation of neuron differentiation
GO:0045740: positive regulation of DNA replication
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048566: embryonic digestive tract development
GO:0048589: developmental growth
GO:0048666: neuron development
GO:0048754: branching morphogenesis of an epithelial tube
GO:0060032: notochord regression
GO:0060322: head development
GO:0060513: prostatic bud formation
GO:0060603: mammary gland duct morphogenesis
GO:0060831: smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0071407: cellular response to organic cyclic compound
GO:0090103: cochlea morphogenesis
GO:0016020: membrane
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0016607: nuclear speck
GO:0031512: motile primary cilium
GO:0005515: protein binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0008270: zinc ion binding
GO:0044212: transcription regulatory region DNA binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4340: Hedgehog signaling pathway
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with GLI2

PMID Title Tumor Value
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
21506130 Role of GLI2 in the growth of human osteosarcoma. yes yes
22968906 Targeting hedgehog-GLI-2 pathway in osteosarcoma. yes yes
title all all