General Information
| Gene ID | 2885 |
|---|---|
| Gene Symbol | GRB2 |
| Gene Name | growth factor receptor-bound protein 2 |
| Gene Type | protein-coding |
| Cytoband | 17q24-q25 |
| Ensembl ID | ENSG00000177885 |
| #miR regulators | 9 |
| Omim ID | 108355 |
| Gene ontology |
GO:0007596: blood coagulation GO:0007173: epidermal growth factor receptor signaling pathway GO:0007265: Ras protein signal transduction GO:0007267: cell-cell signaling GO:0007411: axon guidance GO:0007568: aging GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:2000379: positive regulation of reactive oxygen species metabolic process GO:0048646: anatomical structure formation involved in morphogenesis GO:0019048: modulation by virus of host morphology or physiology GO:0048015: phosphatidylinositol-mediated signaling GO:0030168: platelet activation GO:0030838: positive regulation of actin filament polymerization GO:0031295: T cell costimulation GO:0031623: receptor internalization GO:0038095: Fc-epsilon receptor signaling pathway GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway GO:0042770: signal transduction in response to DNA damage GO:0043408: regulation of MAPK cascade GO:0045087: innate immune response GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050900: leukocyte migration GO:0051291: protein heterooligomerization GO:0060670: branching involved in labyrinthine layer morphogenesis GO:0071479: cellular response to ionizing radiation GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005768: endosome GO:0005794: Golgi apparatus GO:0008180: COP9 signalosome GO:0012506: vesicle membrane GO:0070436: Grb2-EGFR complex GO:0005515: protein binding GO:0001784: phosphotyrosine binding GO:0005070: SH3/SH2 adaptor activity GO:0046875: ephrin receptor binding GO:0005154: epidermal growth factor receptor binding GO:0005168: neurotrophin TRKA receptor binding GO:0042802: identical protein binding GO:0017124: SH3 domain binding GO:0019901: protein kinase binding GO:0019903: protein phosphatase binding GO:0043560: insulin receptor substrate binding |
| KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4320: Dorso-ventral axis formation 4380: Osteoclast differentiation 4510: Focal adhesion 4540: Gap junction 4630: Jak-STAT signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4722: Neurotrophin signaling pathway 4910: Insulin signaling pathway 4912: GnRH signaling pathway 5160: Hepatitis C 5200: Pathways in cancer 5211: Renal cell carcinoma 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no |
| title | all | all |