Results for GRB2

General Information

Gene ID 2885
Gene Symbol GRB2
Gene Name growth factor receptor-bound protein 2
Gene Type protein-coding
Cytoband 17q24-q25
Ensembl ID ENSG00000177885
#miR regulators 9
Omim ID 108355
Gene ontology GO:0007596: blood coagulation
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007265: Ras protein signal transduction
GO:0007267: cell-cell signaling
GO:0007411: axon guidance
GO:0007568: aging
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0048646: anatomical structure formation involved in morphogenesis
GO:0019048: modulation by virus of host morphology or physiology
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030168: platelet activation
GO:0030838: positive regulation of actin filament polymerization
GO:0031295: T cell costimulation
GO:0031623: receptor internalization
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770: signal transduction in response to DNA damage
GO:0043408: regulation of MAPK cascade
GO:0045087: innate immune response
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050900: leukocyte migration
GO:0051291: protein heterooligomerization
GO:0060670: branching involved in labyrinthine layer morphogenesis
GO:0071479: cellular response to ionizing radiation
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005768: endosome
GO:0005794: Golgi apparatus
GO:0008180: COP9 signalosome
GO:0012506: vesicle membrane
GO:0070436: Grb2-EGFR complex
GO:0005515: protein binding
GO:0001784: phosphotyrosine binding
GO:0005070: SH3/SH2 adaptor activity
GO:0046875: ephrin receptor binding
GO:0005154: epidermal growth factor receptor binding
GO:0005168: neurotrophin TRKA receptor binding
GO:0042802: identical protein binding
GO:0017124: SH3 domain binding
GO:0019901: protein kinase binding
GO:0019903: protein phosphatase binding
GO:0043560: insulin receptor substrate binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4320: Dorso-ventral axis formation
4380: Osteoclast differentiation
4510: Focal adhesion
4540: Gap junction
4630: Jak-STAT signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4722: Neurotrophin signaling pathway
4910: Insulin signaling pathway
4912: GnRH signaling pathway
5160: Hepatitis C
5200: Pathways in cancer
5211: Renal cell carcinoma
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with GRB2

PMID Title Tumor Value
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
title all all