Results for NR3C1

General Information

Gene ID 2908
Gene Symbol NR3C1
Gene Name nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Type protein-coding
Cytoband 5q31.3
Ensembl ID ENSG00000113580
#miR regulators 23
Omim ID 138040
Gene ontology GO:0006366: transcription from RNA polymerase II promoter
GO:0007165: signal transduction
GO:0006111: regulation of gluconeogenesis
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0008211: glucocorticoid metabolic process
GO:0010467: gene expression
GO:0016568: chromatin modification
GO:0030325: adrenal gland development
GO:0031946: regulation of glucocorticoid biosynthetic process
GO:0043525: positive regulation of neuron apoptotic process
GO:0060603: mammary gland duct morphogenesis
GO:0016020: membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005759: mitochondrial matrix
GO:0005515: protein binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0004883: glucocorticoid receptor activity
GO:0005496: steroid binding
GO:0046983: protein dimerization activity
GO:0008270: zinc ion binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4080: Neuroactive ligand-receptor interaction

PubMed abstracts associated with NR3C1

PMID Title Tumor Value
7768643 Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. no no
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
10748103 Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells. no no
11155789 Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. no no
11768200 Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. no no
17682054 Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. no no
21527497 Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. no no
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