General Information
Gene ID | 2908 |
---|---|
Gene Symbol | NR3C1 |
Gene Name | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
Gene Type | protein-coding |
Cytoband | 5q31.3 |
Ensembl ID | ENSG00000113580 |
#miR regulators | 23 |
Omim ID | 138040 |
Gene ontology |
GO:0006366: transcription from RNA polymerase II promoter GO:0007165: signal transduction GO:0006111: regulation of gluconeogenesis GO:0006351: transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0008211: glucocorticoid metabolic process GO:0010467: gene expression GO:0016568: chromatin modification GO:0030325: adrenal gland development GO:0031946: regulation of glucocorticoid biosynthetic process GO:0043525: positive regulation of neuron apoptotic process GO:0060603: mammary gland duct morphogenesis GO:0016020: membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005759: mitochondrial matrix GO:0005515: protein binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0004883: glucocorticoid receptor activity GO:0005496: steroid binding GO:0046983: protein dimerization activity GO:0008270: zinc ion binding GO:0043565: sequence-specific DNA binding |
KEGG pathways |
4080: Neuroactive ligand-receptor interaction |
PMID | Title | Tumor | Value |
---|---|---|---|
7768643 | Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. | no | no |
9154817 | Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. | no | no |
10748103 | Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells. | no | no |
11155789 | Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. | no | no |
11768200 | Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. | no | no |
17682054 | Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. | no | no |
21527497 | Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. | no | no |
title | all | all |