Results for GSK3B

General Information

Gene ID 2932
Gene Symbol GSK3B
Gene Name glycogen synthase kinase 3 beta
Gene Type protein-coding
Cytoband 3q13.3
Ensembl ID ENSG00000082701
#miR regulators 12
Omim ID 605004
Gene ontology GO:0000320: re-entry into mitotic cell cycle
GO:0001837: epithelial to mesenchymal transition
GO:0001954: positive regulation of cell-matrix adhesion
GO:0035556: intracellular signal transduction
GO:0005977: glycogen metabolic process
GO:0006349: regulation of gene expression by genetic imprinting
GO:0006468: protein phosphorylation
GO:0006611: protein export from nucleus
GO:0006983: ER overload response
GO:0030010: establishment of cell polarity
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0009887: organ morphogenesis
GO:0007411: axon guidance
GO:0007520: myoblast fusion
GO:0007623: circadian rhythm
GO:0043066: negative regulation of apoptotic process
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042493: response to drug
GO:0010226: response to lithium ion
GO:0010800: positive regulation of peptidyl-threonine phosphorylation
GO:0016477: cell migration
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0018105: peptidyl-serine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021766: hippocampus development
GO:0031333: negative regulation of protein complex assembly
GO:0031334: positive regulation of protein complex assembly
GO:0032091: negative regulation of protein binding
GO:0032092: positive regulation of protein binding
GO:0032855: positive regulation of Rac GTPase activity
GO:0032886: regulation of microtubule-based process
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0035372: protein localization to microtubule
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0043407: negative regulation of MAP kinase activity
GO:0044027: hypermethylation of CpG island
GO:0044337: canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process
GO:0045087: innate immune response
GO:0045444: fat cell differentiation
GO:0045719: negative regulation of glycogen biosynthetic process
GO:0045732: positive regulation of protein catabolic process
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046827: positive regulation of protein export from nucleus
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048168: regulation of neuronal synaptic plasticity
GO:0050774: negative regulation of dendrite morphogenesis
GO:0051534: negative regulation of NFAT protein import into nucleus
GO:0060070: canonical Wnt receptor signaling pathway
GO:0071109: superior temporal gyrus development
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:2000077: negative regulation of type B pancreatic cell development
GO:2000466: negative regulation of glycogen (starch) synthase activity
GO:2000738: positive regulation of stem cell differentiation
GO:0005886: plasma membrane
GO:0030529: ribonucleoprotein complex
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005813: centrosome
GO:0030426: growth cone
GO:0030877: beta-catenin destruction complex
GO:0043025: neuronal cell body
GO:0043197: dendritic spine
GO:0043198: dendritic shaft
GO:0045121: membrane raft
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0001085: RNA polymerase II transcription factor binding
GO:0002039: p53 binding
GO:0004674: protein serine/threonine kinase activity
GO:0005178: integrin binding
GO:0005524: ATP binding
GO:0008013: beta-catenin binding
GO:0016301: kinase activity
GO:0019901: protein kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0034236: protein kinase A catalytic subunit binding
GO:0035255: ionotropic glutamate receptor binding
GO:0048156: tau protein binding
GO:0050321: tau-protein kinase activity
GO:0051059: NF-kappaB binding
KEGG pathways 4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4110: Cell cycle
4310: Wnt signaling pathway
4340: Hedgehog signaling pathway
4360: Axon guidance
4510: Focal adhesion
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4722: Neurotrophin signaling pathway
4910: Insulin signaling pathway
4916: Melanogenesis
5010: Alzheimer's disease
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5213: Endometrial cancer
5215: Prostate cancer
5217: Basal cell carcinoma

PubMed abstracts associated with GSK3B

PMID Title Tumor Value
19882675 Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. yes no
19888226 Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. yes no
20926002 Celecoxib inhibits ?-catenin-dependent survival of the human osteosarcoma MG-63 cell line. no no
21331449 Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. no no
22534782 Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma. no no
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
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