General Information
Gene ID | 2932 |
---|---|
Gene Symbol | GSK3B |
Gene Name | glycogen synthase kinase 3 beta |
Gene Type | protein-coding |
Cytoband | 3q13.3 |
Ensembl ID | ENSG00000082701 |
#miR regulators | 12 |
Omim ID | 605004 |
Gene ontology |
GO:0000320: re-entry into mitotic cell cycle GO:0001837: epithelial to mesenchymal transition GO:0001954: positive regulation of cell-matrix adhesion GO:0035556: intracellular signal transduction GO:0005977: glycogen metabolic process GO:0006349: regulation of gene expression by genetic imprinting GO:0006468: protein phosphorylation GO:0006611: protein export from nucleus GO:0006983: ER overload response GO:0030010: establishment of cell polarity GO:0007173: epidermal growth factor receptor signaling pathway GO:0009887: organ morphogenesis GO:0007411: axon guidance GO:0007520: myoblast fusion GO:0007623: circadian rhythm GO:0043066: negative regulation of apoptotic process GO:0008543: fibroblast growth factor receptor signaling pathway GO:0042493: response to drug GO:0010226: response to lithium ion GO:0010800: positive regulation of peptidyl-threonine phosphorylation GO:0016477: cell migration GO:0045892: negative regulation of transcription, DNA-dependent GO:0018105: peptidyl-serine phosphorylation GO:0048015: phosphatidylinositol-mediated signaling GO:0021766: hippocampus development GO:0031333: negative regulation of protein complex assembly GO:0031334: positive regulation of protein complex assembly GO:0032091: negative regulation of protein binding GO:0032092: positive regulation of protein binding GO:0032855: positive regulation of Rac GTPase activity GO:0032886: regulation of microtubule-based process GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0035372: protein localization to microtubule GO:0038095: Fc-epsilon receptor signaling pathway GO:0043407: negative regulation of MAP kinase activity GO:0044027: hypermethylation of CpG island GO:0044337: canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process GO:0045087: innate immune response GO:0045444: fat cell differentiation GO:0045719: negative regulation of glycogen biosynthetic process GO:0045732: positive regulation of protein catabolic process GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046827: positive regulation of protein export from nucleus GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048168: regulation of neuronal synaptic plasticity GO:0050774: negative regulation of dendrite morphogenesis GO:0051534: negative regulation of NFAT protein import into nucleus GO:0060070: canonical Wnt receptor signaling pathway GO:0071109: superior temporal gyrus development GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:2000077: negative regulation of type B pancreatic cell development GO:2000466: negative regulation of glycogen (starch) synthase activity GO:2000738: positive regulation of stem cell differentiation GO:0005886: plasma membrane GO:0030529: ribonucleoprotein complex GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005813: centrosome GO:0030426: growth cone GO:0030877: beta-catenin destruction complex GO:0043025: neuronal cell body GO:0043197: dendritic spine GO:0043198: dendritic shaft GO:0045121: membrane raft GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0001085: RNA polymerase II transcription factor binding GO:0002039: p53 binding GO:0004674: protein serine/threonine kinase activity GO:0005178: integrin binding GO:0005524: ATP binding GO:0008013: beta-catenin binding GO:0016301: kinase activity GO:0019901: protein kinase binding GO:0031625: ubiquitin protein ligase binding GO:0034236: protein kinase A catalytic subunit binding GO:0035255: ionotropic glutamate receptor binding GO:0048156: tau protein binding GO:0050321: tau-protein kinase activity GO:0051059: NF-kappaB binding |
KEGG pathways |
4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4110: Cell cycle 4310: Wnt signaling pathway 4340: Hedgehog signaling pathway 4360: Axon guidance 4510: Focal adhesion 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4722: Neurotrophin signaling pathway 4910: Insulin signaling pathway 4916: Melanogenesis 5010: Alzheimer's disease 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5213: Endometrial cancer 5215: Prostate cancer 5217: Basal cell carcinoma |
PMID | Title | Tumor | Value |
---|---|---|---|
19882675 | Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. | yes | no |
19888226 | Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. | yes | no |
20926002 | Celecoxib inhibits β-catenin-dependent survival of the human osteosarcoma MG-63 cell line. | no | no |
21331449 | Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. | no | no |
22534782 | Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. | no | no |
23164673 | The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | no | no |
title | all | all |