General Information
Gene ID | 2950 |
---|---|
Gene Symbol | GSTP1 |
Gene Name | glutathione S-transferase pi 1 |
Gene Type | protein-coding |
Cytoband | 11q13 |
Ensembl ID | ENSG00000084207 |
#miR regulators | 2 |
Omim ID | 134660 |
Gene ontology |
GO:0000302: response to reactive oxygen species GO:0002674: negative regulation of acute inflammatory response GO:0006749: glutathione metabolic process GO:0006469: negative regulation of protein kinase activity GO:0006805: xenobiotic metabolic process GO:0007417: central nervous system development GO:0043066: negative regulation of apoptotic process GO:0009890: negative regulation of biosynthetic process GO:0010804: negative regulation of tumor necrosis factor-mediated signaling pathway GO:0032691: negative regulation of interleukin-1 beta production GO:0032720: negative regulation of tumor necrosis factor production GO:0032872: regulation of stress-activated MAPK cascade GO:0032873: negative regulation of stress-activated MAPK cascade GO:0032930: positive regulation of superoxide anion generation GO:0035726: common myeloid progenitor cell proliferation GO:0035732: nitric oxide storage GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043407: negative regulation of MAP kinase activity GO:0043409: negative regulation of MAPK cascade GO:0043508: negative regulation of JUN kinase activity GO:0044281: small molecule metabolic process GO:0048147: negative regulation of fibroblast proliferation GO:0051771: negative regulation of nitric-oxide synthase biosynthetic process GO:0060547: negative regulation of necrotic cell death GO:0070372: regulation of ERK1 and ERK2 cascade GO:0070373: negative regulation of ERK1 and ERK2 cascade GO:0070664: negative regulation of leukocyte proliferation GO:0071222: cellular response to lipopolysaccharide GO:0071638: negative regulation of monocyte chemotactic protein-1 production GO:1901687: glutathione derivative biosynthetic process GO:2001237: negative regulation of extrinsic apoptotic signaling pathway GO:0005622: intracellular GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0097057: TRAF2-GSTP1 complex GO:0005515: protein binding GO:0004364: glutathione transferase activity GO:0008432: JUN kinase binding GO:0019207: kinase regulator activity GO:0035730: S-nitrosoglutathione binding GO:0035731: dinitrosyl-iron complex binding GO:0070026: nitric oxide binding |
KEGG pathways |
480: Glutathione metabolism 980: Metabolism of xenobiotics by cytochrome P450 982: Drug metabolism - cytochrome P450 5200: Pathways in cancer 5215: Prostate cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
9191521 | Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. | yes | yes |
17513610 | Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. | no | no |
18701490 | Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. | no | no |
21887680 | Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. | yes | no |
22068640 | Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. | no | no |
22938445 | Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. | yes | yes |
23317281 | Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. | yes | yes |
title | all | all |