Results for GSTP1

General Information

Gene ID 2950
Gene Symbol GSTP1
Gene Name glutathione S-transferase pi 1
Gene Type protein-coding
Cytoband 11q13
Ensembl ID ENSG00000084207
#miR regulators 2
Omim ID 134660
Gene ontology GO:0000302: response to reactive oxygen species
GO:0002674: negative regulation of acute inflammatory response
GO:0006749: glutathione metabolic process
GO:0006469: negative regulation of protein kinase activity
GO:0006805: xenobiotic metabolic process
GO:0007417: central nervous system development
GO:0043066: negative regulation of apoptotic process
GO:0009890: negative regulation of biosynthetic process
GO:0010804: negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032691: negative regulation of interleukin-1 beta production
GO:0032720: negative regulation of tumor necrosis factor production
GO:0032872: regulation of stress-activated MAPK cascade
GO:0032873: negative regulation of stress-activated MAPK cascade
GO:0032930: positive regulation of superoxide anion generation
GO:0035726: common myeloid progenitor cell proliferation
GO:0035732: nitric oxide storage
GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043407: negative regulation of MAP kinase activity
GO:0043409: negative regulation of MAPK cascade
GO:0043508: negative regulation of JUN kinase activity
GO:0044281: small molecule metabolic process
GO:0048147: negative regulation of fibroblast proliferation
GO:0051771: negative regulation of nitric-oxide synthase biosynthetic process
GO:0060547: negative regulation of necrotic cell death
GO:0070372: regulation of ERK1 and ERK2 cascade
GO:0070373: negative regulation of ERK1 and ERK2 cascade
GO:0070664: negative regulation of leukocyte proliferation
GO:0071222: cellular response to lipopolysaccharide
GO:0071638: negative regulation of monocyte chemotactic protein-1 production
GO:1901687: glutathione derivative biosynthetic process
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:0005622: intracellular
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0097057: TRAF2-GSTP1 complex
GO:0005515: protein binding
GO:0004364: glutathione transferase activity
GO:0008432: JUN kinase binding
GO:0019207: kinase regulator activity
GO:0035730: S-nitrosoglutathione binding
GO:0035731: dinitrosyl-iron complex binding
GO:0070026: nitric oxide binding
KEGG pathways 480: Glutathione metabolism
980: Metabolism of xenobiotics by cytochrome P450
982: Drug metabolism - cytochrome P450
5200: Pathways in cancer
5215: Prostate cancer

PubMed abstracts associated with GSTP1

PMID Title Tumor Value
9191521 Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. yes yes
17513610 Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. no no
18701490 Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. no no
21887680 Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. yes no
22068640 Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. no no
22938445 Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. yes yes
23317281 Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. yes yes
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