General Information
Gene ID | 3014 |
---|---|
Gene Symbol | H2AFX |
Gene Name | H2A histone family, member X |
Gene Type | protein-coding |
Cytoband | 11q23.3 |
Ensembl ID | ENSG00000188486 |
#miR regulators | 3 |
Omim ID | 601772 |
Gene ontology |
GO:0000077: DNA damage checkpoint GO:0000724: double-strand break repair via homologous recombination GO:0006334: nucleosome assembly GO:0006281: DNA repair GO:0006302: double-strand break repair GO:0006974: response to DNA damage stimulus GO:0007126: meiosis GO:0007283: spermatogenesis GO:0010212: response to ionizing radiation GO:0045739: positive regulation of DNA repair GO:0000794: condensed nuclear chromosome GO:0000781: chromosome, telomeric region GO:0000786: nucleosome GO:0000790: nuclear chromatin GO:0001673: male germ cell nucleus GO:0001741: XY body GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005657: replication fork GO:0005515: protein binding GO:0003677: DNA binding GO:0003684: damaged DNA binding GO:0042393: histone binding GO:0019899: enzyme binding GO:0046982: protein heterodimerization activity |
KEGG pathways |
5322: Systemic lupus erythematosus |
PMID | Title | Tumor | Value |
---|---|---|---|
17218778 | Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. | no | no |
17611684 | Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. | no | no |
19159633 | Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. | no | no |
19559722 | Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. | no | no |
title | all | all |