Results for HIF1A

General Information

Gene ID 3091
Gene Symbol HIF1A
Gene Name hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Gene Type protein-coding
Cytoband 14q23.2
Ensembl ID ENSG00000100644
#miR regulators 15
Omim ID 603348
Gene ontology GO:0001525: angiogenesis
GO:0001666: response to hypoxia
GO:0001755: neural crest cell migration
GO:0001837: epithelial to mesenchymal transition
GO:0001892: embryonic placenta development
GO:0001922: B-1 B cell homeostasis
GO:0001938: positive regulation of endothelial cell proliferation
GO:0001947: heart looping
GO:0002052: positive regulation of neuroblast proliferation
GO:0002248: connective tissue replacement involved in inflammatory response wound healing
GO:0003151: outflow tract morphogenesis
GO:0003208: cardiac ventricle morphogenesis
GO:0007165: signal transduction
GO:0006089: lactate metabolic process
GO:0006355: regulation of transcription, DNA-dependent
GO:0006879: cellular iron ion homeostasis
GO:0007219: Notch signaling pathway
GO:0007595: lactation
GO:0008542: visual learning
GO:0010468: regulation of gene expression
GO:0010573: vascular endothelial growth factor production
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0010634: positive regulation of epithelial cell migration
GO:0010870: positive regulation of receptor biosynthetic process
GO:0014850: response to muscle activity
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0046886: positive regulation of hormone biosynthetic process
GO:0019896: axon transport of mitochondrion
GO:0021502: neural fold elevation formation
GO:0021987: cerebral cortex development
GO:0030502: negative regulation of bone mineralization
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007: negative regulation of TOR signaling cascade
GO:0032364: oxygen homeostasis
GO:0032722: positive regulation of chemokine production
GO:0032909: regulation of transforming growth factor beta2 production
GO:0032963: collagen metabolic process
GO:0035162: embryonic hemopoiesis
GO:0035774: positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042541: hemoglobin biosynthetic process
GO:0042593: glucose homeostasis
GO:0042789: mRNA transcription from RNA polymerase II promoter
GO:0043524: negative regulation of neuron apoptotic process
GO:0043619: regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648: positive regulation of erythrocyte differentiation
GO:0045766: positive regulation of angiogenesis
GO:0045821: positive regulation of glycolysis
GO:0045926: negative regulation of growth
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046716: muscle cell cellular homeostasis
GO:0048546: digestive tract morphogenesis
GO:0051000: positive regulation of nitric-oxide synthase activity
GO:0051216: cartilage development
GO:0051541: elastin metabolic process
GO:0060574: intestinal epithelial cell maturation
GO:0061030: epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298: retina vasculature development in camera-type eye
GO:0061418: regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101: positive regulation of chemokine-mediated signaling pathway
GO:0071347: cellular response to interleukin-1
GO:0071456: cellular response to hypoxia
GO:0071542: dopaminergic neuron differentiation
GO:2001054: negative regulation of mesenchymal cell apoptotic process
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005730: nucleolus
GO:0031514: motile cilium
GO:0005515: protein binding
GO:0000988: protein binding transcription factor activity
GO:0001076: RNA polymerase II transcription factor binding transcription factor activity
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871: signal transducer activity
GO:0008134: transcription factor binding
GO:0051879: Hsp90 protein binding
GO:0044212: transcription regulatory region DNA binding
GO:0019899: enzyme binding
GO:0019901: protein kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0035035: histone acetyltransferase binding
GO:0042826: histone deacetylase binding
GO:0043565: sequence-specific DNA binding
GO:0046982: protein heterodimerization activity
KEGG pathways 4150: mTOR signaling pathway
5200: Pathways in cancer
5211: Renal cell carcinoma

PubMed abstracts associated with HIF1A

PMID Title Tumor Value
16798617 Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. no no
17237146 Overexpression of hypoxia-inducible factor-1alpha in human osteosarcoma: correlation with clinicopathological parameters and survival outcome. yes yes
17310851 Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. no no
17980359 Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. no no
18528739 Hypoxia markers in human osteosarcoma: an exploratory study. yes no
18554951 Expression and significance of hypoxemia-inducible factor-1alpha in osteosarcoma of the jaws. yes yes
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no
20637078 Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. no no
20845995 Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1? in osteosarcoma. yes no
22544557 Expression and stability of hypoxia inducible factor 1? in osteosarcoma. yes no
22736026 HIF-1? induced by ?-elemene protects human osteosarcoma cells from undergoing apoptosis. no no
22889802 A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. no no
22992985 Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1?-dependent manner. no no
23879172 FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. no no
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