General Information
Gene ID | 3146 |
---|---|
Gene Symbol | HMGB1 |
Gene Name | high mobility group box 1 |
Gene Type | protein-coding |
Cytoband | 13q12 |
Ensembl ID | ENSG00000189403 |
#miR regulators | 9 |
Omim ID | 163905 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001773: myeloid dendritic cell activation GO:0002407: dendritic cell chemotaxis GO:0002437: inflammatory response to antigenic stimulus GO:0006915: apoptotic process GO:0006265: DNA topological change GO:0006288: base-excision repair, DNA ligation GO:0006309: apoptotic DNA fragmentation GO:0006310: DNA recombination GO:0006357: regulation of transcription from RNA polymerase II promoter GO:0006921: cellular component disassembly involved in execution phase of apoptosis GO:0017055: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0031175: neuron projection development GO:0033151: V(D)J recombination GO:0043065: positive regulation of apoptotic process GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043388: positive regulation of DNA binding GO:0045087: innate immune response GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0050918: positive chemotaxis GO:0051103: DNA ligation involved in DNA repair GO:2000426: negative regulation of apoptotic cell clearance GO:0000793: condensed chromosome GO:0005576: extracellular region GO:0005615: extracellular space GO:0005634: nucleus GO:0005654: nucleoplasm GO:0009986: cell surface GO:0017053: transcriptional repressor complex GO:0005515: protein binding GO:0003684: damaged DNA binding GO:0003690: double-stranded DNA binding GO:0003697: single-stranded DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0005125: cytokine activity GO:0008134: transcription factor binding GO:0008301: DNA binding, bending GO:0042056: chemoattractant activity GO:0050786: RAGE receptor binding GO:0070491: repressing transcription factor binding |
KEGG pathways |
3410: Base excision repair |
PMID | Title | Tumor | Value |
---|---|---|---|
22102692 | HMGB1 promotes drug resistance in osteosarcoma. | no | no |
22301993 | Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. | no | no |
title | all | all |