Results for HMGCR

General Information

Gene ID 3156
Gene Symbol HMGCR
Gene Name 3-hydroxy-3-methylglutaryl-CoA reductase
Gene Type protein-coding
Cytoband 5q13.3-q14
Ensembl ID ENSG00000113161
#miR regulators 14
Omim ID 142910
Gene ontology GO:0006695: cholesterol biosynthetic process
GO:0006743: ubiquinone metabolic process
GO:0009790: embryo development
GO:0007568: aging
GO:0007584: response to nutrient
GO:0008299: isoprenoid biosynthetic process
GO:0008542: visual learning
GO:0010664: negative regulation of striated muscle cell apoptotic process
GO:0010666: positive regulation of cardiac muscle cell apoptotic process
GO:0015936: coenzyme A metabolic process
GO:0032874: positive regulation of stress-activated MAPK cascade
GO:0043407: negative regulation of MAP kinase activity
GO:0044255: cellular lipid metabolic process
GO:0044281: small molecule metabolic process
GO:0045445: myoblast differentiation
GO:0045471: response to ethanol
GO:0045908: negative regulation of vasodilation
GO:0048643: positive regulation of skeletal muscle tissue development
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0051262: protein tetramerization
GO:0061045: negative regulation of wound healing
GO:0061179: negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0016021: integral to membrane
GO:0005783: endoplasmic reticulum
GO:0005778: peroxisomal membrane
GO:0005789: endoplasmic reticulum membrane
GO:0005515: protein binding
GO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0042282: hydroxymethylglutaryl-CoA reductase activity
GO:0042803: protein homodimerization activity
GO:0050662: coenzyme binding
GO:0070402: NADPH binding
KEGG pathways 900: Terpenoid backbone biosynthesis
1100: Metabolic pathways
4976: Bile secretion

PubMed abstracts associated with HMGCR

PMID Title Tumor Value
18252811 Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. no no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
21751201 Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. no no
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