General Information
Gene ID | 3156 |
---|---|
Gene Symbol | HMGCR |
Gene Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
Gene Type | protein-coding |
Cytoband | 5q13.3-q14 |
Ensembl ID | ENSG00000113161 |
#miR regulators | 14 |
Omim ID | 142910 |
Gene ontology |
GO:0006695: cholesterol biosynthetic process GO:0006743: ubiquinone metabolic process GO:0009790: embryo development GO:0007568: aging GO:0007584: response to nutrient GO:0008299: isoprenoid biosynthetic process GO:0008542: visual learning GO:0010664: negative regulation of striated muscle cell apoptotic process GO:0010666: positive regulation of cardiac muscle cell apoptotic process GO:0015936: coenzyme A metabolic process GO:0032874: positive regulation of stress-activated MAPK cascade GO:0043407: negative regulation of MAP kinase activity GO:0044255: cellular lipid metabolic process GO:0044281: small molecule metabolic process GO:0045445: myoblast differentiation GO:0045471: response to ethanol GO:0045908: negative regulation of vasodilation GO:0048643: positive regulation of skeletal muscle tissue development GO:0048661: positive regulation of smooth muscle cell proliferation GO:0051262: protein tetramerization GO:0061045: negative regulation of wound healing GO:0061179: negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0016021: integral to membrane GO:0005783: endoplasmic reticulum GO:0005778: peroxisomal membrane GO:0005789: endoplasmic reticulum membrane GO:0005515: protein binding GO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0042282: hydroxymethylglutaryl-CoA reductase activity GO:0042803: protein homodimerization activity GO:0050662: coenzyme binding GO:0070402: NADPH binding |
KEGG pathways |
900: Terpenoid backbone biosynthesis 1100: Metabolic pathways 4976: Bile secretion |
PMID | Title | Tumor | Value |
---|---|---|---|
18252811 | Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. | no | no |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
21751201 | Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. | no | no |
title | all | all |