Results for APC

General Information

Gene ID 324
Gene Symbol APC
Gene Name adenomatous polyposis coli
Gene Type protein-coding
Cytoband 5q21-q22
Ensembl ID ENSG00000134982
#miR regulators 6
Omim ID 114500 114550 135290 175100 611731 613659
Gene ontology GO:0051276: chromosome organization
GO:0000281: mitotic cytokinesis
GO:0001822: kidney development
GO:0001942: hair follicle development
GO:0006915: apoptotic process
GO:0007155: cell adhesion
GO:0006461: protein complex assembly
GO:0006921: cellular component disassembly involved in execution phase of apoptosis
GO:0006974: response to DNA damage stimulus
GO:0007026: negative regulation of microtubule depolymerization
GO:0007050: cell cycle arrest
GO:0007091: metaphase/anaphase transition of mitotic cell cycle
GO:0007094: mitotic spindle assembly checkpoint
GO:0007409: axonogenesis
GO:0043066: negative regulation of apoptotic process
GO:0008285: negative regulation of cell proliferation
GO:0009798: axis specification
GO:0009952: anterior/posterior pattern specification
GO:0009953: dorsal/ventral pattern formation
GO:0009954: proximal/distal pattern formation
GO:0016477: cell migration
GO:0030335: positive regulation of cell migration
GO:0030858: positive regulation of epithelial cell differentiation
GO:0031116: positive regulation of microtubule polymerization
GO:0031122: cytoplasmic microtubule organization
GO:0031274: positive regulation of pseudopodium assembly
GO:0032886: regulation of microtubule-based process
GO:0033077: T cell differentiation in thymus
GO:0035019: somatic stem cell maintenance
GO:0042483: negative regulation of odontogenesis
GO:0043065: positive regulation of apoptotic process
GO:0043409: negative regulation of MAPK cascade
GO:0045667: regulation of osteoblast differentiation
GO:0045670: regulation of osteoclast differentiation
GO:0045732: positive regulation of protein catabolic process
GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785: positive regulation of cell adhesion
GO:0046716: muscle cell cellular homeostasis
GO:0048538: thymus development
GO:0051171: regulation of nitrogen compound metabolic process
GO:0051781: positive regulation of cell division
GO:0051988: regulation of attachment of spindle microtubules to kinetochore
GO:0060041: retina development in camera-type eye
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060770: negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070830: tight junction assembly
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0005886: plasma membrane
GO:0000776: kinetochore
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005813: centrosome
GO:0005881: cytoplasmic microtubule
GO:0005913: cell-cell adherens junction
GO:0005923: tight junction
GO:0016328: lateral plasma membrane
GO:0030027: lamellipodium
GO:0030877: beta-catenin destruction complex
GO:0032587: ruffle membrane
GO:0035371: microtubule plus end
GO:0044295: axonal growth cone
GO:0005515: protein binding
GO:0008013: beta-catenin binding
GO:0008017: microtubule binding
GO:0019887: protein kinase regulator activity
GO:0019901: protein kinase binding
GO:0045295: gamma-catenin binding
GO:0051010: microtubule plus-end binding
KEGG pathways 4310: Wnt signaling pathway
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5210: Colorectal cancer
5213: Endometrial cancer
5217: Basal cell carcinoma

PubMed abstracts associated with APC

PMID Title Tumor Value
9083931 Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues. yes no
15900593 Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. yes yes
17786187 Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. yes yes
20594821 Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. yes no
title all all