General Information
Gene ID | 324 |
---|---|
Gene Symbol | APC |
Gene Name | adenomatous polyposis coli |
Gene Type | protein-coding |
Cytoband | 5q21-q22 |
Ensembl ID | ENSG00000134982 |
#miR regulators | 6 |
Omim ID | 114500 114550 135290 175100 611731 613659 |
Gene ontology |
GO:0051276: chromosome organization GO:0000281: mitotic cytokinesis GO:0001822: kidney development GO:0001942: hair follicle development GO:0006915: apoptotic process GO:0007155: cell adhesion GO:0006461: protein complex assembly GO:0006921: cellular component disassembly involved in execution phase of apoptosis GO:0006974: response to DNA damage stimulus GO:0007026: negative regulation of microtubule depolymerization GO:0007050: cell cycle arrest GO:0007091: metaphase/anaphase transition of mitotic cell cycle GO:0007094: mitotic spindle assembly checkpoint GO:0007409: axonogenesis GO:0043066: negative regulation of apoptotic process GO:0008285: negative regulation of cell proliferation GO:0009798: axis specification GO:0009952: anterior/posterior pattern specification GO:0009953: dorsal/ventral pattern formation GO:0009954: proximal/distal pattern formation GO:0016477: cell migration GO:0030335: positive regulation of cell migration GO:0030858: positive regulation of epithelial cell differentiation GO:0031116: positive regulation of microtubule polymerization GO:0031122: cytoplasmic microtubule organization GO:0031274: positive regulation of pseudopodium assembly GO:0032886: regulation of microtubule-based process GO:0033077: T cell differentiation in thymus GO:0035019: somatic stem cell maintenance GO:0042483: negative regulation of odontogenesis GO:0043065: positive regulation of apoptotic process GO:0043409: negative regulation of MAPK cascade GO:0045667: regulation of osteoblast differentiation GO:0045670: regulation of osteoclast differentiation GO:0045732: positive regulation of protein catabolic process GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045785: positive regulation of cell adhesion GO:0046716: muscle cell cellular homeostasis GO:0048538: thymus development GO:0051171: regulation of nitrogen compound metabolic process GO:0051781: positive regulation of cell division GO:0051988: regulation of attachment of spindle microtubules to kinetochore GO:0060041: retina development in camera-type eye GO:0060070: canonical Wnt receptor signaling pathway GO:0060770: negative regulation of epithelial cell proliferation involved in prostate gland development GO:0070830: tight junction assembly GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:0005886: plasma membrane GO:0000776: kinetochore GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005813: centrosome GO:0005881: cytoplasmic microtubule GO:0005913: cell-cell adherens junction GO:0005923: tight junction GO:0016328: lateral plasma membrane GO:0030027: lamellipodium GO:0030877: beta-catenin destruction complex GO:0032587: ruffle membrane GO:0035371: microtubule plus end GO:0044295: axonal growth cone GO:0005515: protein binding GO:0008013: beta-catenin binding GO:0008017: microtubule binding GO:0019887: protein kinase regulator activity GO:0019901: protein kinase binding GO:0045295: gamma-catenin binding GO:0051010: microtubule plus-end binding |
KEGG pathways |
4310: Wnt signaling pathway 4810: Regulation of actin cytoskeleton 5200: Pathways in cancer 5210: Colorectal cancer 5213: Endometrial cancer 5217: Basal cell carcinoma |
PMID | Title | Tumor | Value |
---|---|---|---|
9083931 | Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues. | yes | no |
15900593 | Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. | yes | yes |
17786187 | Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. | yes | yes |
20594821 | Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. | yes | no |
title | all | all |