General Information
Gene ID | 3265 |
---|---|
Gene Symbol | HRAS |
Gene Name | v-Ha-ras Harvey rat sarcoma viral oncogene homolog |
Gene Type | protein-coding |
Cytoband | 11p15.5 |
Ensembl ID | ENSG00000174775 |
#miR regulators | --- |
Omim ID | 109800 162900 163200 188470 190020 218040 |
Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0001934: positive regulation of protein phosphorylation GO:0030036: actin cytoskeleton organization GO:0007596: blood coagulation GO:0007165: signal transduction GO:0006897: endocytosis GO:0006935: chemotaxis GO:0007050: cell cycle arrest GO:0007093: mitotic cell cycle checkpoint GO:0007166: cell surface receptor signaling pathway GO:0007173: epidermal growth factor receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0007268: synaptic transmission GO:0009887: organ morphogenesis GO:0007411: axon guidance GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008286: insulin receptor signaling pathway GO:0008542: visual learning GO:0008543: fibroblast growth factor receptor signaling pathway GO:0010629: negative regulation of gene expression GO:0030335: positive regulation of cell migration GO:0032228: regulation of synaptic transmission, GABAergic GO:0032855: positive regulation of Rac GTPase activity GO:0034259: negative regulation of Rho GTPase activity GO:0035022: positive regulation of Rac protein signal transduction GO:0035176: social behavior GO:0038095: Fc-epsilon receptor signaling pathway GO:0043406: positive regulation of MAP kinase activity GO:0043410: positive regulation of MAPK cascade GO:0043524: negative regulation of neuron apoptotic process GO:0045087: innate immune response GO:0045740: positive regulation of DNA replication GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046330: positive regulation of JNK cascade GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048169: regulation of long-term neuronal synaptic plasticity GO:0050679: positive regulation of epithelial cell proliferation GO:0050900: leukocyte migration GO:0051146: striated muscle cell differentiation GO:0051291: protein heterooligomerization GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0090303: positive regulation of wound healing GO:0090398: cellular senescence GO:0097193: intrinsic apoptotic signaling pathway GO:1900029: positive regulation of ruffle assembly GO:2000251: positive regulation of actin cytoskeleton reorganization GO:2000630: positive regulation of miRNA metabolic process GO:0005886: plasma membrane GO:0000139: Golgi membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005794: Golgi apparatus GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0003924: GTPase activity GO:0005525: GTP binding GO:0008022: protein C-terminus binding |
KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4144: Endocytosis 4360: Axon guidance 4370: VEGF signaling pathway 4510: Focal adhesion 4530: Tight junction 4540: Gap junction 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4720: Long-term potentiation 4722: Neurotrophin signaling pathway 4730: Long-term depression 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4916: Melanogenesis 5160: Hepatitis C 5200: Pathways in cancer 5211: Renal cell carcinoma 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5216: Thyroid cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
7850751 | Mutational activation of ras genes is absent in pediatric osteosarcoma. | yes | no |
10453987 | Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. | no | no |
12181274 | Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. | yes | no |
15310147 | Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. | yes | no |
15492501 | Differential oncogenic Ras signaling and senescence in tumor cells. | no | no |
title | all | all |