Results for HRAS

General Information

Gene ID 3265
Gene Symbol HRAS
Gene Name v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Gene Type protein-coding
Cytoband 11p15.5
Ensembl ID ENSG00000174775
#miR regulators ---
Omim ID 109800 162900 163200 188470 190020 218040
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0001934: positive regulation of protein phosphorylation
GO:0030036: actin cytoskeleton organization
GO:0007596: blood coagulation
GO:0007165: signal transduction
GO:0006897: endocytosis
GO:0006935: chemotaxis
GO:0007050: cell cycle arrest
GO:0007093: mitotic cell cycle checkpoint
GO:0007166: cell surface receptor signaling pathway
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0007268: synaptic transmission
GO:0009887: organ morphogenesis
GO:0007411: axon guidance
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008542: visual learning
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010629: negative regulation of gene expression
GO:0030335: positive regulation of cell migration
GO:0032228: regulation of synaptic transmission, GABAergic
GO:0032855: positive regulation of Rac GTPase activity
GO:0034259: negative regulation of Rho GTPase activity
GO:0035022: positive regulation of Rac protein signal transduction
GO:0035176: social behavior
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0043406: positive regulation of MAP kinase activity
GO:0043410: positive regulation of MAPK cascade
GO:0043524: negative regulation of neuron apoptotic process
GO:0045087: innate immune response
GO:0045740: positive regulation of DNA replication
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046330: positive regulation of JNK cascade
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048169: regulation of long-term neuronal synaptic plasticity
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050900: leukocyte migration
GO:0051146: striated muscle cell differentiation
GO:0051291: protein heterooligomerization
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0090303: positive regulation of wound healing
GO:0090398: cellular senescence
GO:0097193: intrinsic apoptotic signaling pathway
GO:1900029: positive regulation of ruffle assembly
GO:2000251: positive regulation of actin cytoskeleton reorganization
GO:2000630: positive regulation of miRNA metabolic process
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005794: Golgi apparatus
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0003924: GTPase activity
GO:0005525: GTP binding
GO:0008022: protein C-terminus binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4144: Endocytosis
4360: Axon guidance
4370: VEGF signaling pathway
4510: Focal adhesion
4530: Tight junction
4540: Gap junction
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4720: Long-term potentiation
4722: Neurotrophin signaling pathway
4730: Long-term depression
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4916: Melanogenesis
5160: Hepatitis C
5200: Pathways in cancer
5211: Renal cell carcinoma
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5216: Thyroid cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with HRAS

PMID Title Tumor Value
7850751 Mutational activation of ras genes is absent in pediatric osteosarcoma. yes no
10453987 Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. no no
12181274 Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. yes no
15310147 Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. yes no
15492501 Differential oncogenic Ras signaling and senescence in tumor cells. no no
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