Results for APEX1

General Information

Gene ID 328
Gene Symbol APEX1
Gene Name APEX nuclease (multifunctional DNA repair enzyme) 1
Gene Type protein-coding
Cytoband 14q11.2
Ensembl ID ENSG00000100823
#miR regulators 1
Omim ID 107748
Gene ontology GO:0055114: oxidation-reduction process
GO:0045454: cell redox homeostasis
GO:0006281: DNA repair
GO:0006284: base-excision repair
GO:0006310: DNA recombination
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0007568: aging
GO:0042493: response to drug
GO:0014912: negative regulation of smooth muscle cell migration
GO:0043488: regulation of mRNA stability
GO:0045739: positive regulation of DNA repair
GO:0070301: cellular response to hydrogen peroxide
GO:0071320: cellular response to cAMP
GO:0071375: cellular response to peptide hormone stimulus
GO:0080111: DNA demethylation
GO:0005739: mitochondrion
GO:0005783: endoplasmic reticulum
GO:0005840: ribosome
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005730: nucleolus
GO:0005813: centrosome
GO:0016607: nuclear speck
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003684: damaged DNA binding
GO:0003713: transcription coactivator activity
GO:0003714: transcription corepressor activity
GO:0003723: RNA binding
GO:0003906: DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519: endonuclease activity
GO:0004520: endodeoxyribonuclease activity
GO:0004523: ribonuclease H activity
GO:0004528: phosphodiesterase I activity
GO:0004844: uracil DNA N-glycosylase activity
GO:0046872: metal ion binding
GO:0016491: oxidoreductase activity
GO:0008081: phosphoric diester hydrolase activity
GO:0008408: 3'-5' exonuclease activity
GO:0016890: site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490: chromatin DNA binding
GO:0032403: protein complex binding
GO:0051059: NF-kappaB binding
KEGG pathways 3410: Base excision repair

PubMed abstracts associated with APEX1

PMID Title Tumor Value
15210853 Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. yes yes
17892509 Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. no no
20218738 APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. yes yes
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