Results for HES1

General Information

Gene ID 3280
Gene Symbol HES1
Gene Name hairy and enhancer of split 1, (Drosophila)
Gene Type protein-coding
Cytoband 3q28-q29
Ensembl ID ENSG00000114315
#miR regulators 6
Omim ID 139605
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001889: liver development
GO:0003143: embryonic heart tube morphogenesis
GO:0003151: outflow tract morphogenesis
GO:0003266: regulation of secondary heart field cardioblast proliferation
GO:0003281: ventricular septum development
GO:0007155: cell adhesion
GO:0006461: protein complex assembly
GO:0007219: Notch signaling pathway
GO:0007224: smoothened signaling pathway
GO:0007262: STAT protein import into nucleus
GO:0007399: nervous system development
GO:0008284: positive regulation of cell proliferation
GO:0016477: cell migration
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021537: telencephalon development
GO:0021555: midbrain-hindbrain boundary morphogenesis
GO:0021557: oculomotor nerve development
GO:0021558: trochlear nerve development
GO:0021575: hindbrain morphogenesis
GO:0021861: forebrain radial glial cell differentiation
GO:0021984: adenohypophysis development
GO:0030324: lung development
GO:0030513: positive regulation of BMP signaling pathway
GO:0030901: midbrain development
GO:0031018: endocrine pancreas development
GO:0035019: somatic stem cell maintenance
GO:0035910: ascending aorta morphogenesis
GO:0042102: positive regulation of T cell proliferation
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668: auditory receptor cell fate determination
GO:0043388: positive regulation of DNA binding
GO:0045598: regulation of fat cell differentiation
GO:0045608: negative regulation of auditory receptor cell differentiation
GO:0045747: positive regulation of Notch signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0045977: positive regulation of mitotic cell cycle, embryonic
GO:0046331: lateral inhibition
GO:0046427: positive regulation of JAK-STAT cascade
GO:0048469: cell maturation
GO:0048538: thymus development
GO:0048667: cell morphogenesis involved in neuron differentiation
GO:0048711: positive regulation of astrocyte differentiation
GO:0048715: negative regulation of oligodendrocyte differentiation
GO:0048844: artery morphogenesis
GO:0060037: pharyngeal system development
GO:0060164: regulation of timing of neuron differentiation
GO:0060253: negative regulation of glial cell proliferation
GO:0060412: ventricular septum morphogenesis
GO:0060675: ureteric bud morphogenesis
GO:0060716: labyrinthine layer blood vessel development
GO:0061009: common bile duct development
GO:0061106: negative regulation of stomach neuroendocrine cell differentiation
GO:0061309: cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0072012: glomerulus vasculature development
GO:0072049: comma-shaped body morphogenesis
GO:0072050: S-shaped body morphogenesis
GO:0072141: renal interstitial cell development
GO:0072282: metanephric nephron tubule morphogenesis
GO:0090102: cochlea development
GO:0097084: vascular smooth muscle cell development
GO:0097150: neuronal stem cell maintenance
GO:2000227: negative regulation of pancreatic A cell differentiation
GO:2000737: negative regulation of stem cell differentiation
GO:2000974: negative regulation of pro-B cell differentiation
GO:2000978: negative regulation of forebrain neuron differentiation
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0008134: transcription factor binding
GO:0042803: protein homodimerization activity
GO:0042826: histone deacetylase binding
GO:0043565: sequence-specific DNA binding
GO:0071820: N-box binding
KEGG pathways 4330: Notch signaling pathway
4950: Maturity onset diabetes of the young

PubMed abstracts associated with HES1

PMID Title Tumor Value
18483362 Critical role of notch signaling in osteosarcoma invasion and metastasis. yes yes
19228774 Notch signaling contributes to the pathogenesis of human osteosarcomas. no no
20208568 Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. no no
20213410 How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. no yes
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no
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