Results for XIAP

General Information

Gene ID 331
Gene Symbol XIAP
Gene Name X-linked inhibitor of apoptosis
Gene Type protein-coding
Cytoband Xq25
Ensembl ID ENSG00000101966 ENSG00000270294
#miR regulators 11
Omim ID 300079 300635 308240
Gene ontology GO:0006915: apoptotic process
GO:0016055: Wnt receptor signaling pathway
GO:0006974: response to DNA damage stimulus
GO:0043066: negative regulation of apoptotic process
GO:0030510: regulation of BMP signaling pathway
GO:0042127: regulation of cell proliferation
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045088: regulation of innate immune response
GO:0050727: regulation of inflammatory response
GO:0055070: copper ion homeostasis
GO:0070424: regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0090263: positive regulation of canonical Wnt receptor signaling pathway
GO:0097193: intrinsic apoptotic signaling pathway
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005515: protein binding
GO:0004842: ubiquitin-protein ligase activity
GO:0008270: zinc ion binding
GO:0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
KEGG pathways 4120: Ubiquitin mediated proteolysis
4210: Apoptosis
4510: Focal adhesion
4621: NOD-like receptor signaling pathway
5145: Toxoplasmosis
5200: Pathways in cancer
5222: Small cell lung cancer

PubMed abstracts associated with XIAP

PMID Title Tumor Value
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no
16327988 Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. no no
16982772 Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. no no
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no
20808934 Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. no no
21286665 Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. no no
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
23232982 Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-?B pathway. no no
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