Results for BIRC5

General Information

Gene ID 332
Gene Symbol BIRC5
Gene Name baculoviral IAP repeat containing 5
Gene Type protein-coding
Cytoband 17q25
Ensembl ID ENSG00000089685
#miR regulators 4
Omim ID 603352
Gene ontology GO:0007059: chromosome segregation
GO:0000086: G2/M transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0000910: cytokinesis
GO:0006915: apoptotic process
GO:0006351: transcription, DNA-dependent
GO:0006468: protein phosphorylation
GO:0007067: mitosis
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0031503: protein complex localization
GO:0031536: positive regulation of exit from mitosis
GO:0031577: spindle checkpoint
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045931: positive regulation of mitotic cell cycle
GO:0051301: cell division
GO:0051303: establishment of chromosome localization
GO:0000228: nuclear chromosome
GO:0000775: chromosome, centromeric region
GO:0000777: condensed chromosome kinetochore
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005814: centriole
GO:0005819: spindle
GO:0005874: microtubule
GO:0005876: spindle microtubule
GO:0005881: cytoplasmic microtubule
GO:0030496: midbody
GO:0031021: interphase microtubule organizing center
GO:0032133: chromosome passenger complex
GO:0005515: protein binding
GO:0051087: chaperone binding
GO:0004869: cysteine-type endopeptidase inhibitor activity
GO:0046872: metal ion binding
GO:0008536: Ran GTPase binding
GO:0008017: microtubule binding
GO:0008270: zinc ion binding
GO:0042802: identical protein binding
GO:0015631: tubulin binding
GO:0019899: enzyme binding
GO:0042803: protein homodimerization activity
GO:0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046982: protein heterodimerization activity
GO:0048037: cofactor binding
GO:0050897: cobalt ion binding
KEGG pathways 5200: Pathways in cancer
5210: Colorectal cancer

PubMed abstracts associated with BIRC5

PMID Title Tumor Value
12711293 Survivin expression in human osteosarcoma is a marker for survival. yes yes
16705726 Expression of survivin and correlation with PCNA in osteosarcoma. yes yes
17034065 Survivin expression levels as independent predictors of survival for osteosarcoma patients. yes yes
18097539 Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines. no no
18996209 Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro. no no
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no
19212684 The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. yes yes
19730790 Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/?-catenin antagonists against human osteosarcoma cells. no no
20459702 Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. yes no
20682173 Sensitization of osteosarcoma cell line SaOS-2 to chemotherapy by downregulating survivin. no no
20845987 +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. no no
21527497 Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. no no
22922684 The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. yes no
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
23232982 Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-?B pathway. no no
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