General Information
Gene ID | 332 |
---|---|
Gene Symbol | BIRC5 |
Gene Name | baculoviral IAP repeat containing 5 |
Gene Type | protein-coding |
Cytoband | 17q25 |
Ensembl ID | ENSG00000089685 |
#miR regulators | 4 |
Omim ID | 603352 |
Gene ontology |
GO:0007059: chromosome segregation GO:0000086: G2/M transition of mitotic cell cycle GO:0000278: mitotic cell cycle GO:0000910: cytokinesis GO:0006915: apoptotic process GO:0006351: transcription, DNA-dependent GO:0006468: protein phosphorylation GO:0007067: mitosis GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0045892: negative regulation of transcription, DNA-dependent GO:0031503: protein complex localization GO:0031536: positive regulation of exit from mitosis GO:0031577: spindle checkpoint GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045931: positive regulation of mitotic cell cycle GO:0051301: cell division GO:0051303: establishment of chromosome localization GO:0000228: nuclear chromosome GO:0000775: chromosome, centromeric region GO:0000777: condensed chromosome kinetochore GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005814: centriole GO:0005819: spindle GO:0005874: microtubule GO:0005876: spindle microtubule GO:0005881: cytoplasmic microtubule GO:0030496: midbody GO:0031021: interphase microtubule organizing center GO:0032133: chromosome passenger complex GO:0005515: protein binding GO:0051087: chaperone binding GO:0004869: cysteine-type endopeptidase inhibitor activity GO:0046872: metal ion binding GO:0008536: Ran GTPase binding GO:0008017: microtubule binding GO:0008270: zinc ion binding GO:0042802: identical protein binding GO:0015631: tubulin binding GO:0019899: enzyme binding GO:0042803: protein homodimerization activity GO:0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0046982: protein heterodimerization activity GO:0048037: cofactor binding GO:0050897: cobalt ion binding |
KEGG pathways |
5200: Pathways in cancer 5210: Colorectal cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
12711293 | Survivin expression in human osteosarcoma is a marker for survival. | yes | yes |
16705726 | Expression of survivin and correlation with PCNA in osteosarcoma. | yes | yes |
17034065 | Survivin expression levels as independent predictors of survival for osteosarcoma patients. | yes | yes |
18097539 | Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines. | no | no |
18996209 | Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro. | no | no |
19160414 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. | no | no |
19212684 | The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. | yes | yes |
19730790 | Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. | no | no |
20459702 | Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. | yes | no |
20682173 | Sensitization of osteosarcoma cell line SaOS-2 to chemotherapy by downregulating survivin. | no | no |
20845987 | +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. | no | no |
21527497 | Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. | no | no |
22922684 | The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. | yes | no |
23164673 | The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | no | no |
23232982 | Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. | no | no |
title | all | all |