General Information
| Gene ID | 3320 |
|---|---|
| Gene Symbol | HSP90AA1 |
| Gene Name | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| Gene Type | protein-coding |
| Cytoband | 14q32.33 |
| Ensembl ID | ENSG00000080824 |
| #miR regulators | 5 |
| Omim ID | 140571 |
| Gene ontology |
GO:0000086: G2/M transition of mitotic cell cycle GO:0000278: mitotic cell cycle GO:0006986: response to unfolded protein GO:0042026: protein refolding GO:0007165: signal transduction GO:0006200: ATP catabolic process GO:0051131: chaperone-mediated protein complex assembly GO:0006839: mitochondrial transport GO:0007411: axon guidance GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis GO:0044281: small molecule metabolic process GO:0045040: protein import into mitochondrial outer membrane GO:0045087: innate immune response GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0046209: nitric oxide metabolic process GO:0050999: regulation of nitric-oxide synthase activity GO:0005886: plasma membrane GO:0005576: extracellular region GO:0005829: cytosol GO:0042470: melanosome GO:0071682: endocytic vesicle lumen GO:0051082: unfolded protein binding GO:0000166: nucleotide binding GO:0005515: protein binding GO:0005524: ATP binding GO:0016887: ATPase activity GO:0042802: identical protein binding GO:0030235: nitric-oxide synthase regulator activity GO:0030911: TPR domain binding GO:0042803: protein homodimerization activity |
| KEGG pathways |
4141: Protein processing in endoplasmic reticulum 4612: Antigen processing and presentation 4621: NOD-like receptor signaling pathway 4914: Progesterone-mediated oocyte maturation 5200: Pathways in cancer 5215: Prostate cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 10638971 | Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. | yes | yes |
| 11087053 | Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. | yes | yes |
| 11156738 | Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. | no | no |
| 15455381 | Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. | no | no |
| 19148492 | Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. | no | no |
| 23027359 | Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. | no | no |
| title | all | all |