Results for HSP90AA1

General Information

Gene ID 3320
Gene Symbol HSP90AA1
Gene Name heat shock protein 90kDa alpha (cytosolic), class A member 1
Gene Type protein-coding
Cytoband 14q32.33
Ensembl ID ENSG00000080824
#miR regulators 5
Omim ID 140571
Gene ontology GO:0000086: G2/M transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0006986: response to unfolded protein
GO:0042026: protein refolding
GO:0007165: signal transduction
GO:0006200: ATP catabolic process
GO:0051131: chaperone-mediated protein complex assembly
GO:0006839: mitochondrial transport
GO:0007411: axon guidance
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281: small molecule metabolic process
GO:0045040: protein import into mitochondrial outer membrane
GO:0045087: innate immune response
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0046209: nitric oxide metabolic process
GO:0050999: regulation of nitric-oxide synthase activity
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0042470: melanosome
GO:0071682: endocytic vesicle lumen
GO:0051082: unfolded protein binding
GO:0000166: nucleotide binding
GO:0005515: protein binding
GO:0005524: ATP binding
GO:0016887: ATPase activity
GO:0042802: identical protein binding
GO:0030235: nitric-oxide synthase regulator activity
GO:0030911: TPR domain binding
GO:0042803: protein homodimerization activity
KEGG pathways 4141: Protein processing in endoplasmic reticulum
4612: Antigen processing and presentation
4621: NOD-like receptor signaling pathway
4914: Progesterone-mediated oocyte maturation
5200: Pathways in cancer
5215: Prostate cancer

PubMed abstracts associated with HSP90AA1

PMID Title Tumor Value
10638971 Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. yes yes
11087053 Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. yes yes
11156738 Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. no no
15455381 Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. no no
19148492 Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. no no
23027359 Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. no no
title all all