Results for ICAM1

General Information

Gene ID 3383
Gene Symbol ICAM1
Gene Name intercellular adhesion molecule 1
Gene Type protein-coding
Cytoband 19p13.3-p13.2
Ensembl ID ENSG00000090339
#miR regulators 8
Omim ID 147840 611162
Gene ontology GO:0001541: ovarian follicle development
GO:0007157: heterophilic cell-cell adhesion
GO:0001910: regulation of leukocyte mediated cytotoxicity
GO:0001975: response to amphetamine
GO:0002291: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0002457: T cell antigen processing and presentation
GO:0002693: positive regulation of cellular extravasation
GO:0007155: cell adhesion
GO:0007159: leukocyte cell-cell adhesion
GO:0007569: cell aging
GO:0008360: regulation of cell shape
GO:0042493: response to drug
GO:0010212: response to ionizing radiation
GO:0010477: response to sulfur dioxide
GO:0014070: response to organic cyclic compound
GO:0019048: modulation by virus of host morphology or physiology
GO:0019221: cytokine-mediated signaling pathway
GO:0022614: membrane to membrane docking
GO:0030155: regulation of cell adhesion
GO:0031669: cellular response to nutrient levels
GO:0033627: cell adhesion mediated by integrin
GO:0034698: response to gonadotropin stimulus
GO:0043200: response to amino acid stimulus
GO:0046688: response to copper ion
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045471: response to ethanol
GO:0045907: positive regulation of vasoconstriction
GO:0046813: virion attachment, binding of host cell surface receptor
GO:0050776: regulation of immune response
GO:0050900: leukocyte migration
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051856: adhesion to symbiont
GO:0051926: negative regulation of calcium ion transport
GO:0060333: interferon-gamma-mediated signaling pathway
GO:0071222: cellular response to lipopolysaccharide
GO:0071312: cellular response to alkaloid
GO:0071333: cellular response to glucose stimulus
GO:0071347: cellular response to interleukin-1
GO:0071356: cellular response to tumor necrosis factor
GO:0071456: cellular response to hypoxia
GO:0005886: plasma membrane
GO:0001772: immunological synapse
GO:0005887: integral to plasma membrane
GO:0005615: extracellular space
GO:0009897: external side of plasma membrane
GO:0005515: protein binding
GO:0001618: virus receptor activity
GO:0004872: receptor activity
GO:0004888: transmembrane signaling receptor activity
GO:0005178: integrin binding
KEGG pathways 4514: Cell adhesion molecules (CAMs)
4650: Natural killer cell mediated cytotoxicity
4670: Leukocyte transendothelial migration
5143: African trypanosomiasis
5144: Malaria
5150: Staphylococcus aureus infection
5323: Rheumatoid arthritis
5416: Viral myocarditis

PubMed abstracts associated with ICAM1

PMID Title Tumor Value
9109391 Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNF alpha incubation. no no
9664132 TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. no no
10536172 NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. no no
14660053 Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. no no
16798617 Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. no no
19584295 Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. no no
22939995 IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. yes no
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