General Information
Gene ID | 3383 |
---|---|
Gene Symbol | ICAM1 |
Gene Name | intercellular adhesion molecule 1 |
Gene Type | protein-coding |
Cytoband | 19p13.3-p13.2 |
Ensembl ID | ENSG00000090339 |
#miR regulators | 8 |
Omim ID | 147840 611162 |
Gene ontology |
GO:0001541: ovarian follicle development GO:0007157: heterophilic cell-cell adhesion GO:0001910: regulation of leukocyte mediated cytotoxicity GO:0001975: response to amphetamine GO:0002291: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002457: T cell antigen processing and presentation GO:0002693: positive regulation of cellular extravasation GO:0007155: cell adhesion GO:0007159: leukocyte cell-cell adhesion GO:0007569: cell aging GO:0008360: regulation of cell shape GO:0042493: response to drug GO:0010212: response to ionizing radiation GO:0010477: response to sulfur dioxide GO:0014070: response to organic cyclic compound GO:0019048: modulation by virus of host morphology or physiology GO:0019221: cytokine-mediated signaling pathway GO:0022614: membrane to membrane docking GO:0030155: regulation of cell adhesion GO:0031669: cellular response to nutrient levels GO:0033627: cell adhesion mediated by integrin GO:0034698: response to gonadotropin stimulus GO:0043200: response to amino acid stimulus GO:0046688: response to copper ion GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0045471: response to ethanol GO:0045907: positive regulation of vasoconstriction GO:0046813: virion attachment, binding of host cell surface receptor GO:0050776: regulation of immune response GO:0050900: leukocyte migration GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051856: adhesion to symbiont GO:0051926: negative regulation of calcium ion transport GO:0060333: interferon-gamma-mediated signaling pathway GO:0071222: cellular response to lipopolysaccharide GO:0071312: cellular response to alkaloid GO:0071333: cellular response to glucose stimulus GO:0071347: cellular response to interleukin-1 GO:0071356: cellular response to tumor necrosis factor GO:0071456: cellular response to hypoxia GO:0005886: plasma membrane GO:0001772: immunological synapse GO:0005887: integral to plasma membrane GO:0005615: extracellular space GO:0009897: external side of plasma membrane GO:0005515: protein binding GO:0001618: virus receptor activity GO:0004872: receptor activity GO:0004888: transmembrane signaling receptor activity GO:0005178: integrin binding |
KEGG pathways |
4514: Cell adhesion molecules (CAMs) 4650: Natural killer cell mediated cytotoxicity 4670: Leukocyte transendothelial migration 5143: African trypanosomiasis 5144: Malaria 5150: Staphylococcus aureus infection 5323: Rheumatoid arthritis 5416: Viral myocarditis |
PMID | Title | Tumor | Value |
---|---|---|---|
9109391 | Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNF alpha incubation. | no | no |
9664132 | TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. | no | no |
10536172 | NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. | no | no |
14660053 | Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. | no | no |
16798617 | Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. | no | no |
19584295 | Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. | no | no |
22939995 | IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. | yes | no |
title | all | all |