Results for IFNG

General Information

Gene ID 3458
Gene Symbol IFNG
Gene Name interferon, gamma
Gene Type protein-coding
Cytoband 12q14
Ensembl ID ENSG00000111537
#miR regulators 11
Omim ID 147570 607948 609135 609423 609532 613254
Gene ontology GO:0000060: protein import into nucleus, translocation
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001781: neutrophil apoptotic process
GO:0002026: regulation of the force of heart contraction
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002250: adaptive immune response
GO:0002302: CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0003340: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0042742: defense response to bacterium
GO:0009615: response to virus
GO:0006915: apoptotic process
GO:0006928: cellular component movement
GO:0006959: humoral immune response
GO:0007050: cell cycle arrest
GO:0007166: cell surface receptor signaling pathway
GO:0050796: regulation of insulin secretion
GO:0042493: response to drug
GO:0019221: cytokine-mediated signaling pathway
GO:0019882: antigen processing and presentation
GO:0030593: neutrophil chemotaxis
GO:0030968: endoplasmic reticulum unfolded protein response
GO:0031642: negative regulation of myelination
GO:0032224: positive regulation of synaptic transmission, cholinergic
GO:0032700: negative regulation of interleukin-17 production
GO:0032735: positive regulation of interleukin-12 production
GO:0032747: positive regulation of interleukin-23 production
GO:0032760: positive regulation of tumor necrosis factor production
GO:0033141: positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0044130: negative regulation of growth of symbiont in host
GO:0034393: positive regulation of smooth muscle cell apoptotic process
GO:0042102: positive regulation of T cell proliferation
GO:0042511: positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042832: defense response to protozoan
GO:0045080: positive regulation of chemokine biosynthetic process
GO:0045084: positive regulation of interleukin-12 biosynthetic process
GO:0045348: positive regulation of MHC class II biosynthetic process
GO:0045410: positive regulation of interleukin-6 biosynthetic process
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045666: positive regulation of neuron differentiation
GO:0045672: positive regulation of osteoclast differentiation
GO:0045785: positive regulation of cell adhesion
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048304: positive regulation of isotype switching to IgG isotypes
GO:0048662: negative regulation of smooth muscle cell proliferation
GO:0050718: positive regulation of interleukin-1 beta secretion
GO:0051044: positive regulation of membrane protein ectodomain proteolysis
GO:0051607: defense response to virus
GO:0051712: positive regulation of killing of cells of other organism
GO:0060333: interferon-gamma-mediated signaling pathway
GO:0060334: regulation of interferon-gamma-mediated signaling pathway
GO:0060550: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552: positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557: positive regulation of vitamin D biosynthetic process
GO:0060559: positive regulation of calcidiol 1-monooxygenase activity
GO:0071222: cellular response to lipopolysaccharide
GO:0071351: cellular response to interleukin-18
GO:0072308: negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0097191: extrinsic apoptotic signaling pathway
GO:2000309: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0009897: external side of plasma membrane
GO:0005125: cytokine activity
GO:0005133: interferon-gamma receptor binding
KEGG pathways 3050: Proteasome
4060: Cytokine-cytokine receptor interaction
4140: Regulation of autophagy
4350: TGF-beta signaling pathway
4380: Osteoclast differentiation
4612: Antigen processing and presentation
4630: Jak-STAT signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4940: Type I diabetes mellitus
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5144: Malaria
5145: Toxoplasmosis
5146: Amoebiasis
5322: Systemic lupus erythematosus
5323: Rheumatoid arthritis
5330: Allograft rejection
5332: Graft-versus-host disease

PubMed abstracts associated with IFNG

PMID Title Tumor Value
1932372 Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. no no
14660053 Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. no no
15055356 Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. no no
15298715 Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. yes no
15318945 Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. no no
15390286 Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. no no
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