General Information
Gene ID | 3458 |
---|---|
Gene Symbol | IFNG |
Gene Name | interferon, gamma |
Gene Type | protein-coding |
Cytoband | 12q14 |
Ensembl ID | ENSG00000111537 |
#miR regulators | 11 |
Omim ID | 147570 607948 609135 609423 609532 613254 |
Gene ontology |
GO:0000060: protein import into nucleus, translocation GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001781: neutrophil apoptotic process GO:0002026: regulation of the force of heart contraction GO:0002053: positive regulation of mesenchymal cell proliferation GO:0002250: adaptive immune response GO:0002302: CD8-positive, alpha-beta T cell differentiation involved in immune response GO:0003340: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0042742: defense response to bacterium GO:0009615: response to virus GO:0006915: apoptotic process GO:0006928: cellular component movement GO:0006959: humoral immune response GO:0007050: cell cycle arrest GO:0007166: cell surface receptor signaling pathway GO:0050796: regulation of insulin secretion GO:0042493: response to drug GO:0019221: cytokine-mediated signaling pathway GO:0019882: antigen processing and presentation GO:0030593: neutrophil chemotaxis GO:0030968: endoplasmic reticulum unfolded protein response GO:0031642: negative regulation of myelination GO:0032224: positive regulation of synaptic transmission, cholinergic GO:0032700: negative regulation of interleukin-17 production GO:0032735: positive regulation of interleukin-12 production GO:0032747: positive regulation of interleukin-23 production GO:0032760: positive regulation of tumor necrosis factor production GO:0033141: positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0044130: negative regulation of growth of symbiont in host GO:0034393: positive regulation of smooth muscle cell apoptotic process GO:0042102: positive regulation of T cell proliferation GO:0042511: positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042832: defense response to protozoan GO:0045080: positive regulation of chemokine biosynthetic process GO:0045084: positive regulation of interleukin-12 biosynthetic process GO:0045348: positive regulation of MHC class II biosynthetic process GO:0045410: positive regulation of interleukin-6 biosynthetic process GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0045666: positive regulation of neuron differentiation GO:0045672: positive regulation of osteoclast differentiation GO:0045785: positive regulation of cell adhesion GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048304: positive regulation of isotype switching to IgG isotypes GO:0048662: negative regulation of smooth muscle cell proliferation GO:0050718: positive regulation of interleukin-1 beta secretion GO:0051044: positive regulation of membrane protein ectodomain proteolysis GO:0051607: defense response to virus GO:0051712: positive regulation of killing of cells of other organism GO:0060333: interferon-gamma-mediated signaling pathway GO:0060334: regulation of interferon-gamma-mediated signaling pathway GO:0060550: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity GO:0060552: positive regulation of fructose 1,6-bisphosphate metabolic process GO:0060557: positive regulation of vitamin D biosynthetic process GO:0060559: positive regulation of calcidiol 1-monooxygenase activity GO:0071222: cellular response to lipopolysaccharide GO:0071351: cellular response to interleukin-18 GO:0072308: negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0097191: extrinsic apoptotic signaling pathway GO:2000309: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:0005576: extracellular region GO:0005615: extracellular space GO:0009897: external side of plasma membrane GO:0005125: cytokine activity GO:0005133: interferon-gamma receptor binding |
KEGG pathways |
3050: Proteasome 4060: Cytokine-cytokine receptor interaction 4140: Regulation of autophagy 4350: TGF-beta signaling pathway 4380: Osteoclast differentiation 4612: Antigen processing and presentation 4630: Jak-STAT signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4940: Type I diabetes mellitus 5140: Leishmaniasis 5142: Chagas disease (American trypanosomiasis) 5143: African trypanosomiasis 5144: Malaria 5145: Toxoplasmosis 5146: Amoebiasis 5322: Systemic lupus erythematosus 5323: Rheumatoid arthritis 5330: Allograft rejection 5332: Graft-versus-host disease |
PMID | Title | Tumor | Value |
---|---|---|---|
1932372 | Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. | no | no |
14660053 | Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. | no | no |
15055356 | Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. | no | no |
15298715 | Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. | yes | no |
15318945 | Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. | no | no |
15390286 | Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. | no | no |
title | all | all |