Results for IGF1

General Information

Gene ID 3479
Gene Symbol IGF1
Gene Name insulin-like growth factor 1 (somatomedin C)
Gene Type protein-coding
Cytoband 12q23.2
Ensembl ID ENSG00000017427
#miR regulators 21
Omim ID 147440 608747
Gene ontology GO:0006260: DNA replication
GO:0001501: skeletal system development
GO:0001974: blood vessel remodeling
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0007165: signal transduction
GO:0006928: cellular component movement
GO:0007265: Ras protein signal transduction
GO:0007517: muscle organ development
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0009441: glycolate metabolic process
GO:0010001: glial cell differentiation
GO:0010613: positive regulation of cardiac muscle hypertrophy
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0014834: satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896: muscle hypertrophy
GO:0014904: myotube cell development
GO:0014911: positive regulation of smooth muscle cell migration
GO:0046326: positive regulation of glucose import
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021940: positive regulation of cerebellar granule cell precursor proliferation
GO:0030104: water homeostasis
GO:0030166: proteoglycan biosynthetic process
GO:0030168: platelet activation
GO:0030879: mammary gland development
GO:0031017: exocrine pancreas development
GO:0032878: regulation of establishment or maintenance of cell polarity
GO:0033160: positive regulation of protein import into nucleus, translocation
GO:0034392: negative regulation of smooth muscle cell apoptotic process
GO:0035264: multicellular organism growth
GO:0035630: bone mineralization involved in bone maturation
GO:0040014: regulation of multicellular organism growth
GO:0042104: positive regulation of activated T cell proliferation
GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043388: positive regulation of DNA binding
GO:0043410: positive regulation of MAPK cascade
GO:0043568: positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267: cellular protein metabolic process
GO:0045445: myoblast differentiation
GO:0045669: positive regulation of osteoblast differentiation
GO:0045725: positive regulation of glycogen biosynthetic process
GO:0045740: positive regulation of DNA replication
GO:0045821: positive regulation of glycolysis
GO:0045840: positive regulation of mitosis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046579: positive regulation of Ras protein signal transduction
GO:0048009: insulin-like growth factor receptor signaling pathway
GO:0048146: positive regulation of fibroblast proliferation
GO:0048286: lung alveolus development
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0048754: branching morphogenesis of an epithelial tube
GO:0048839: inner ear development
GO:0050650: chondroitin sulfate proteoglycan biosynthetic process
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0051450: myoblast proliferation
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060426: lung vasculature development
GO:0060463: lung lobe morphogenesis
GO:0060509: Type I pneumocyte differentiation
GO:0060510: Type II pneumocyte differentiation
GO:0060527: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736: prostate gland growth
GO:0060741: prostate gland stromal morphogenesis
GO:0060766: negative regulation of androgen receptor signaling pathway
GO:0070373: negative regulation of ERK1 and ERK2 cascade
GO:0070886: positive regulation of calcineurin-NFAT signaling cascade
GO:0090201: negative regulation of release of cytochrome c from mitochondria
GO:2000288: positive regulation of myoblast proliferation
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0016942: insulin-like growth factor binding protein complex
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0005158: insulin receptor binding
GO:0005159: insulin-like growth factor receptor binding
GO:0005178: integrin binding
GO:0005179: hormone activity
GO:0008083: growth factor activity
KEGG pathways 4114: Oocyte meiosis
4115: p53 signaling pathway
4150: mTOR signaling pathway
4510: Focal adhesion
4730: Long-term depression
4914: Progesterone-mediated oocyte maturation
4960: Aldosterone-regulated sodium reabsorption
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5410: Hypertrophic cardiomyopathy (HCM)
5414: Dilated cardiomyopathy

PubMed abstracts associated with IGF1

PMID Title Tumor Value
2153840 Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma. no no
2166171 Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. no no
7473836 Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. no no
7684391 Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. no no
8052269 Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. no no
8168113 Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. no no
8281940 Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
9762887 Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. yes no
10234573 ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. no no
10453987 Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. no no
10726973 Insulin-like growth factor-I inhibits the progression of human U-2 OS osteosarcoma cells towards programmed cell death through interaction with the IGF-I receptor. no no
11344491 Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. yes no
11454519 Effects of IGF-I and -II, IGF binding protein-3 (IGFBP-3), and transforming growth factor-beta (TGF-beta) on growth and apoptosis of human osteosarcoma Saos-2/B-10 cells: lack of IGF-independent IGFBP-3 effects. no no
12218590 Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels. yes no
15095405 IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. no no
16475708 Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. no no
17372931 Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. no no
19258511 Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. yes no
21321933 Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells. yes no
21520041 Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. no no
21619704 A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. yes yes
title all all