Results for IGF1R

General Information

Gene ID 3480
Gene Symbol IGF1R
Gene Name insulin-like growth factor 1 receptor
Gene Type protein-coding
Cytoband 15q26.3
Ensembl ID ENSG00000140443
#miR regulators 6
Omim ID 147370 270450
Gene ontology GO:0007165: signal transduction
GO:0006955: immune response
GO:0030010: establishment of cell polarity
GO:0007409: axonogenesis
GO:0007420: brain development
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0014065: phosphatidylinositol 3-kinase cascade
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030238: male sex determination
GO:0030335: positive regulation of cell migration
GO:0030879: mammary gland development
GO:0031017: exocrine pancreas development
GO:0032467: positive regulation of cytokinesis
GO:0033197: response to vitamin E
GO:0043410: positive regulation of MAPK cascade
GO:0045740: positive regulation of DNA replication
GO:0046328: regulation of JNK cascade
GO:0046777: protein autophosphorylation
GO:0048009: insulin-like growth factor receptor signaling pathway
GO:0051262: protein tetramerization
GO:0051291: protein heterooligomerization
GO:0051389: inactivation of MAPKK activity
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0051898: negative regulation of protein kinase B signaling cascade
GO:0060740: prostate gland epithelium morphogenesis
GO:0090031: positive regulation of steroid hormone biosynthetic process
GO:0005886: plasma membrane
GO:0016020: membrane
GO:0005887: integral to plasma membrane
GO:0043231: intracellular membrane-bounded organelle
GO:0005901: caveola
GO:0043005: neuron projection
GO:0005515: protein binding
GO:0001965: G-protein alpha-subunit binding
GO:0004713: protein tyrosine kinase activity
GO:0005010: insulin-like growth factor-activated receptor activity
GO:0005158: insulin receptor binding
GO:0005520: insulin-like growth factor binding
GO:0005524: ATP binding
GO:0042802: identical protein binding
GO:0031994: insulin-like growth factor I binding
GO:0043548: phosphatidylinositol 3-kinase binding
GO:0043559: insulin binding
GO:0043560: insulin receptor substrate binding
KEGG pathways 4114: Oocyte meiosis
4144: Endocytosis
4510: Focal adhesion
4520: Adherens junction
4730: Long-term depression
4914: Progesterone-mediated oocyte maturation
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma

PubMed abstracts associated with IGF1R

PMID Title Tumor Value
2153840 Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma. no no
8168113 Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. no no
9492043 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. no no
9762887 Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. yes no
9935160 Redundancy of autocrine loops in human osteosarcoma cells. no no
10726973 Insulin-like growth factor-I inhibits the progression of human U-2 OS osteosarcoma cells towards programmed cell death through interaction with the IGF-I receptor. no no
15055356 Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. no no
15095405 IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. no no
15455381 Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. no no
17372931 Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. no no
18607665 Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. no no
19229591 Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. no no
19258511 Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. yes no
19638450 Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. no no
19789339 The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. no no
20376536 Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. no no
20486173 R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. no no
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
21751203 Cell surface receptor expression patterns in osteosarcoma. yes no
21843050 IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. no no
21866554 Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. yes yes
22682017 Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. yes yes
23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. yes no
23527718 The role and clinical significance of YES-associated protein 1 in human osteosarcoma. no yes
title all all