General Information
Gene ID | 3480 |
---|---|
Gene Symbol | IGF1R |
Gene Name | insulin-like growth factor 1 receptor |
Gene Type | protein-coding |
Cytoband | 15q26.3 |
Ensembl ID | ENSG00000140443 |
#miR regulators | 6 |
Omim ID | 147370 270450 |
Gene ontology |
GO:0007165: signal transduction GO:0006955: immune response GO:0030010: establishment of cell polarity GO:0007409: axonogenesis GO:0007420: brain development GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0008286: insulin receptor signaling pathway GO:0014065: phosphatidylinositol 3-kinase cascade GO:0048015: phosphatidylinositol-mediated signaling GO:0030238: male sex determination GO:0030335: positive regulation of cell migration GO:0030879: mammary gland development GO:0031017: exocrine pancreas development GO:0032467: positive regulation of cytokinesis GO:0033197: response to vitamin E GO:0043410: positive regulation of MAPK cascade GO:0045740: positive regulation of DNA replication GO:0046328: regulation of JNK cascade GO:0046777: protein autophosphorylation GO:0048009: insulin-like growth factor receptor signaling pathway GO:0051262: protein tetramerization GO:0051291: protein heterooligomerization GO:0051389: inactivation of MAPKK activity GO:0051897: positive regulation of protein kinase B signaling cascade GO:0051898: negative regulation of protein kinase B signaling cascade GO:0060740: prostate gland epithelium morphogenesis GO:0090031: positive regulation of steroid hormone biosynthetic process GO:0005886: plasma membrane GO:0016020: membrane GO:0005887: integral to plasma membrane GO:0043231: intracellular membrane-bounded organelle GO:0005901: caveola GO:0043005: neuron projection GO:0005515: protein binding GO:0001965: G-protein alpha-subunit binding GO:0004713: protein tyrosine kinase activity GO:0005010: insulin-like growth factor-activated receptor activity GO:0005158: insulin receptor binding GO:0005520: insulin-like growth factor binding GO:0005524: ATP binding GO:0042802: identical protein binding GO:0031994: insulin-like growth factor I binding GO:0043548: phosphatidylinositol 3-kinase binding GO:0043559: insulin binding GO:0043560: insulin receptor substrate binding |
KEGG pathways |
4114: Oocyte meiosis 4144: Endocytosis 4510: Focal adhesion 4520: Adherens junction 4730: Long-term depression 4914: Progesterone-mediated oocyte maturation 5200: Pathways in cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma |
PMID | Title | Tumor | Value |
---|---|---|---|
2153840 | Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma. | no | no |
8168113 | Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. | no | no |
9492043 | p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. | no | no |
9762887 | Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. | yes | no |
9935160 | Redundancy of autocrine loops in human osteosarcoma cells. | no | no |
10726973 | Insulin-like growth factor-I inhibits the progression of human U-2 OS osteosarcoma cells towards programmed cell death through interaction with the IGF-I receptor. | no | no |
15055356 | Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. | no | no |
15095405 | IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. | no | no |
15455381 | Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. | no | no |
17372931 | Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. | no | no |
18607665 | Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. | no | no |
19229591 | Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. | no | no |
19258511 | Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. | yes | no |
19638450 | Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. | no | no |
19789339 | The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. | no | no |
20376536 | Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. | no | no |
20486173 | R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. | no | no |
21667022 | The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. | no | no |
21751203 | Cell surface receptor expression patterns in osteosarcoma. | yes | no |
21843050 | IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. | no | no |
21866554 | Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. | yes | yes |
22682017 | Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. | yes | yes |
23507142 | miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. | yes | no |
23527718 | The role and clinical significance of YES-associated protein 1 in human osteosarcoma. | no | yes |
title | all | all |