Results for IGF2

General Information

Gene ID 3481
Gene Symbol IGF2
Gene Name insulin-like growth factor 2 (somatomedin A)
Gene Type protein-coding
Cytoband 11p15.5
Ensembl ID ENSG00000167244
#miR regulators 2
Omim ID 130650 147470
Gene ontology GO:0001501: skeletal system development
GO:0001503: ossification
GO:0001934: positive regulation of protein phosphorylation
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0006006: glucose metabolic process
GO:0006349: regulation of gene expression by genetic imprinting
GO:0006355: regulation of transcription, DNA-dependent
GO:0007275: multicellular organismal development
GO:0008284: positive regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0030168: platelet activation
GO:0038028: insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade
GO:0042104: positive regulation of activated T cell proliferation
GO:0043085: positive regulation of catalytic activity
GO:0043410: positive regulation of MAPK cascade
GO:0044267: cellular protein metabolic process
GO:0045725: positive regulation of glycogen biosynthetic process
GO:0045840: positive regulation of mitosis
GO:0046628: positive regulation of insulin receptor signaling pathway
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781: positive regulation of cell division
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0071902: positive regulation of protein serine/threonine kinase activity
GO:2000273: positive regulation of receptor activity
GO:2000467: positive regulation of glycogen (starch) synthase activity
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0005158: insulin receptor binding
GO:0005159: insulin-like growth factor receptor binding
GO:0005179: hormone activity
GO:0008083: growth factor activity
GO:0030546: receptor activator activity
GO:0043539: protein serine/threonine kinase activator activity
KEGG pathways ---

PubMed abstracts associated with IGF2

PMID Title Tumor Value
7789337 Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures. no no
9762887 Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. yes no
11454519 Effects of IGF-I and -II, IGF binding protein-3 (IGFBP-3), and transforming growth factor-beta (TGF-beta) on growth and apoptosis of human osteosarcoma Saos-2/B-10 cells: lack of IGF-independent IGFBP-3 effects. no no
12588801 Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. yes no
17372931 Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. no no
19258511 Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. yes no
19427670 Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma. yes no
22042095 The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. yes no
23527718 The role and clinical significance of YES-associated protein 1 in human osteosarcoma. no yes
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