Results for IGFBP3

General Information

Gene ID 3486
Gene Symbol IGFBP3
Gene Name insulin-like growth factor binding protein 3
Gene Type protein-coding
Cytoband 7p13-p12
Ensembl ID ENSG00000146674
#miR regulators 15
Omim ID 146732
Gene ontology GO:0001558: regulation of cell growth
GO:0001933: negative regulation of protein phosphorylation
GO:0006915: apoptotic process
GO:0006468: protein phosphorylation
GO:0008285: negative regulation of cell proliferation
GO:0009968: negative regulation of signal transduction
GO:0010906: regulation of glucose metabolic process
GO:0014912: negative regulation of smooth muscle cell migration
GO:0043065: positive regulation of apoptotic process
GO:0043410: positive regulation of MAPK cascade
GO:0043568: positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267: cellular protein metabolic process
GO:0044342: type B pancreatic cell proliferation
GO:0045663: positive regulation of myoblast differentiation
GO:0048662: negative regulation of smooth muscle cell proliferation
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0016942: insulin-like growth factor binding protein complex
GO:0005515: protein binding
GO:0001968: fibronectin binding
GO:0046872: metal ion binding
GO:0005520: insulin-like growth factor binding
GO:0008160: protein tyrosine phosphatase activator activity
GO:0031994: insulin-like growth factor I binding
KEGG pathways 4115: p53 signaling pathway

PubMed abstracts associated with IGFBP3

PMID Title Tumor Value
8550801 1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentiation and growth arrest in a human osteosarcoma cell line. no no
11344491 Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. yes no
11454519 Effects of IGF-I and -II, IGF binding protein-3 (IGFBP-3), and transforming growth factor-beta (TGF-beta) on growth and apoptosis of human osteosarcoma Saos-2/B-10 cells: lack of IGF-independent IGFBP-3 effects. no no
12218590 Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels. yes no
15095405 IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. no no
17372931 Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. no no
19192721 Expression of insulin-like growth factor-II mRNA binding protein 3 (IMP3) in osteosarcoma. yes yes
19596932 Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. yes yes
20340016 Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcoma. yes no
21520041 Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. no no
22682017 Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. yes yes
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