General Information
Gene ID | 355 |
---|---|
Gene Symbol | FAS |
Gene Name | Fas (TNF receptor superfamily, member 6) |
Gene Type | protein-coding |
Cytoband | 10q24.1 |
Ensembl ID | ENSG00000026103 |
#miR regulators | 12 |
Omim ID | 134637 601859 |
Gene ontology |
GO:0002377: immunoglobulin production GO:0003014: renal system process GO:0006915: apoptotic process GO:0007165: signal transduction GO:0006461: protein complex assembly GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006924: activation-induced cell death of T cells GO:0006925: inflammatory cell apoptotic process GO:0006927: transformed cell apoptotic process GO:0043066: negative regulation of apoptotic process GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0009636: response to toxic substance GO:0010467: gene expression GO:0010940: positive regulation of necrotic cell death GO:0042981: regulation of apoptotic process GO:0019724: B cell mediated immunity GO:0071260: cellular response to mechanical stimulus GO:0032464: positive regulation of protein homooligomerization GO:0051260: protein homooligomerization GO:0043065: positive regulation of apoptotic process GO:0045060: negative thymic T cell selection GO:0045619: regulation of lymphocyte differentiation GO:0045637: regulation of myeloid cell differentiation GO:0048536: spleen development GO:0050869: negative regulation of B cell activation GO:0051384: response to glucocorticoid stimulus GO:0051402: neuron apoptotic process GO:0071285: cellular response to lithium ion GO:0071455: cellular response to hyperoxia GO:0097190: apoptotic signaling pathway GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005576: extracellular region GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0009897: external side of plasma membrane GO:0031264: death-inducing signaling complex GO:0031265: CD95 death-inducing signaling complex GO:0045121: membrane raft GO:0005515: protein binding GO:0004871: signal transducer activity GO:0004872: receptor activity GO:0004888: transmembrane signaling receptor activity GO:0042802: identical protein binding GO:0019900: kinase binding |
KEGG pathways |
4010: MAPK signaling pathway 4060: Cytokine-cytokine receptor interaction 4115: p53 signaling pathway 4210: Apoptosis 4650: Natural killer cell mediated cytotoxicity 4940: Type I diabetes mellitus 5010: Alzheimer's disease 5142: Chagas disease (American trypanosomiasis) 5143: African trypanosomiasis 5200: Pathways in cancer 5320: Autoimmune thyroid disease 5330: Allograft rejection 5332: Graft-versus-host disease |
PMID | Title | Tumor | Value |
---|---|---|---|
10232607 | Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. | no | no |
10568818 | Modulation of fas-mediated apoptosis in osteosarcoma cell lines. | no | no |
10571205 | A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. | no | no |
11093825 | Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. | no | no |
11358827 | Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. | no | yes |
12168884 | Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. | yes | yes |
14647441 | FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. | no | no |
14760101 | Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. | no | no |
15207713 | Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. | no | no |
15390286 | Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. | no | no |
15540114 | Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. | no | no |
15585647 | Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. | yes | no |
16282894 | Fas expression in lung metastasis from osteosarcoma patients. | yes | yes |
16380506 | Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. | no | no |
17611696 | Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. | no | no |
18090928 | Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. | yes | no |
18414033 | Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. | no | no |
18771083 | VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. | no | no |
19066961 | Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death. | no | no |
20213411 | The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. | no | no |
20819644 | Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. | no | no |
20845987 | +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. | no | no |
21287529 | Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. | no | no |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
21717192 | Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. | no | no |
22186140 | miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. | no | no |
title | all | all |