Results for FAS

General Information

Gene ID 355
Gene Symbol FAS
Gene Name Fas (TNF receptor superfamily, member 6)
Gene Type protein-coding
Cytoband 10q24.1
Ensembl ID ENSG00000026103
#miR regulators 12
Omim ID 134637 601859
Gene ontology GO:0002377: immunoglobulin production
GO:0003014: renal system process
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006461: protein complex assembly
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924: activation-induced cell death of T cells
GO:0006925: inflammatory cell apoptotic process
GO:0006927: transformed cell apoptotic process
GO:0043066: negative regulation of apoptotic process
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636: response to toxic substance
GO:0010467: gene expression
GO:0010940: positive regulation of necrotic cell death
GO:0042981: regulation of apoptotic process
GO:0019724: B cell mediated immunity
GO:0071260: cellular response to mechanical stimulus
GO:0032464: positive regulation of protein homooligomerization
GO:0051260: protein homooligomerization
GO:0043065: positive regulation of apoptotic process
GO:0045060: negative thymic T cell selection
GO:0045619: regulation of lymphocyte differentiation
GO:0045637: regulation of myeloid cell differentiation
GO:0048536: spleen development
GO:0050869: negative regulation of B cell activation
GO:0051384: response to glucocorticoid stimulus
GO:0051402: neuron apoptotic process
GO:0071285: cellular response to lithium ion
GO:0071455: cellular response to hyperoxia
GO:0097190: apoptotic signaling pathway
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0009897: external side of plasma membrane
GO:0031264: death-inducing signaling complex
GO:0031265: CD95 death-inducing signaling complex
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0004871: signal transducer activity
GO:0004872: receptor activity
GO:0004888: transmembrane signaling receptor activity
GO:0042802: identical protein binding
GO:0019900: kinase binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4115: p53 signaling pathway
4210: Apoptosis
4650: Natural killer cell mediated cytotoxicity
4940: Type I diabetes mellitus
5010: Alzheimer's disease
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5200: Pathways in cancer
5320: Autoimmune thyroid disease
5330: Allograft rejection
5332: Graft-versus-host disease

PubMed abstracts associated with FAS

PMID Title Tumor Value
10232607 Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. no no
10568818 Modulation of fas-mediated apoptosis in osteosarcoma cell lines. no no
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no
11358827 Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. no yes
12168884 Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. yes yes
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no
14760101 Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. no no
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no
15390286 Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. no no
15540114 Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. no no
15585647 Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. yes no
16282894 Fas expression in lung metastasis from osteosarcoma patients. yes yes
16380506 Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. no no
17611696 Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. no no
18090928 Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. yes no
18414033 Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. no no
18771083 VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. no no
19066961 Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death. no no
20213411 The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. no no
20819644 Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. no no
20845987 +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. no no
21287529 Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no
22186140 miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. no no
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