General Information
Gene ID | 3552 |
---|---|
Gene Symbol | IL1A |
Gene Name | interleukin 1, alpha |
Gene Type | protein-coding |
Cytoband | 2q14 |
Ensembl ID | ENSG00000115008 |
#miR regulators | 9 |
Omim ID | 147760 |
Gene ontology |
GO:0001660: fever generation GO:0006915: apoptotic process GO:0006954: inflammatory response GO:0006955: immune response GO:0008283: cell proliferation GO:0008285: negative regulation of cell proliferation GO:0010575: positive regulation vascular endothelial growth factor production GO:0019221: cytokine-mediated signaling pathway GO:0034605: cellular response to heat GO:0045086: positive regulation of interleukin-2 biosynthetic process GO:0046688: response to copper ion GO:0045766: positive regulation of angiogenesis GO:0045840: positive regulation of mitosis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0050715: positive regulation of cytokine secretion GO:0051781: positive regulation of cell division GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005576: extracellular region GO:0005829: cytosol GO:0005615: extracellular space GO:0005515: protein binding GO:0005125: cytokine activity GO:0005149: interleukin-1 receptor binding GO:0005507: copper ion binding |
KEGG pathways |
4010: MAPK signaling pathway 4060: Cytokine-cytokine receptor interaction 4210: Apoptosis 4380: Osteoclast differentiation 4640: Hematopoietic cell lineage 4940: Type I diabetes mellitus 5020: Prion diseases 5140: Leishmaniasis 5323: Rheumatoid arthritis 5332: Graft-versus-host disease |
PMID | Title | Tumor | Value |
---|---|---|---|
7502710 | Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. | no | no |
8276785 | Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. | no | no |
9703989 | Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. | no | no |
9858899 | Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. | no | no |
12415617 | Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells. | no | no |
15923123 | Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). | no | no |
title | all | all |