Results for IL1A

General Information

Gene ID 3552
Gene Symbol IL1A
Gene Name interleukin 1, alpha
Gene Type protein-coding
Cytoband 2q14
Ensembl ID ENSG00000115008
#miR regulators 9
Omim ID 147760
Gene ontology GO:0001660: fever generation
GO:0006915: apoptotic process
GO:0006954: inflammatory response
GO:0006955: immune response
GO:0008283: cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0019221: cytokine-mediated signaling pathway
GO:0034605: cellular response to heat
GO:0045086: positive regulation of interleukin-2 biosynthetic process
GO:0046688: response to copper ion
GO:0045766: positive regulation of angiogenesis
GO:0045840: positive regulation of mitosis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0050715: positive regulation of cytokine secretion
GO:0051781: positive regulation of cell division
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005615: extracellular space
GO:0005515: protein binding
GO:0005125: cytokine activity
GO:0005149: interleukin-1 receptor binding
GO:0005507: copper ion binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4210: Apoptosis
4380: Osteoclast differentiation
4640: Hematopoietic cell lineage
4940: Type I diabetes mellitus
5020: Prion diseases
5140: Leishmaniasis
5323: Rheumatoid arthritis
5332: Graft-versus-host disease

PubMed abstracts associated with IL1A

PMID Title Tumor Value
7502710 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. no no
8276785 Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. no no
9703989 Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. no no
9858899 Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. no no
12415617 Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells. no no
15923123 Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). no no
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