Results for IL1B

General Information

Gene ID 3553
Gene Symbol IL1B
Gene Name interleukin 1, beta
Gene Type protein-coding
Cytoband 2q14
Ensembl ID ENSG00000125538
#miR regulators 2
Omim ID 137215 147720
Gene ontology GO:0000165: MAPK cascade
GO:0000187: activation of MAPK activity
GO:0001660: fever generation
GO:0001934: positive regulation of protein phosphorylation
GO:0002711: positive regulation of T cell mediated immunity
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006954: inflammatory response
GO:0006955: immune response
GO:0007267: cell-cell signaling
GO:0007566: embryo implantation
GO:0050796: regulation of insulin secretion
GO:0008285: negative regulation of cell proliferation
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0010829: negative regulation of glucose transport
GO:0014805: smooth muscle adaptation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0019221: cytokine-mediated signaling pathway
GO:0071260: cellular response to mechanical stimulus
GO:0030213: hyaluronan biosynthetic process
GO:0030593: neutrophil chemotaxis
GO:0030730: sequestering of triglyceride
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031622: positive regulation of fever generation
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0032308: positive regulation of prostaglandin secretion
GO:0032611: interleukin-1 beta production
GO:0032725: positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729: positive regulation of interferon-gamma production
GO:0032755: positive regulation of interleukin-6 production
GO:0032757: positive regulation of interleukin-8 production
GO:0033129: positive regulation of histone phosphorylation
GO:0033198: response to ATP
GO:0034116: positive regulation of heterotypic cell-cell adhesion
GO:0035066: positive regulation of histone acetylation
GO:0035505: positive regulation of myosin light chain kinase activity
GO:0035690: cellular response to drug
GO:0042102: positive regulation of T cell proliferation
GO:0042346: positive regulation of NF-kappaB import into nucleus
GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043407: negative regulation of MAP kinase activity
GO:0043491: protein kinase B signaling cascade
GO:0045080: positive regulation of chemokine biosynthetic process
GO:0045086: positive regulation of interleukin-2 biosynthetic process
GO:0045410: positive regulation of interleukin-6 biosynthetic process
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045766: positive regulation of angiogenesis
GO:0045833: negative regulation of lipid metabolic process
GO:0045840: positive regulation of mitosis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046330: positive regulation of JNK cascade
GO:0046627: negative regulation of insulin receptor signaling pathway
GO:0046827: positive regulation of protein export from nucleus
GO:0050995: negative regulation of lipid catabolic process
GO:0050996: positive regulation of lipid catabolic process
GO:0051044: positive regulation of membrane protein ectodomain proteolysis
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051781: positive regulation of cell division
GO:0060355: positive regulation of cell adhesion molecule production
GO:0060559: positive regulation of calcidiol 1-monooxygenase activity
GO:0070164: negative regulation of adiponectin secretion
GO:0070487: monocyte aggregation
GO:0071310: cellular response to organic substance
GO:0071407: cellular response to organic cyclic compound
GO:0071639: positive regulation of monocyte chemotactic protein-1 production
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005615: extracellular space
GO:0030141: secretory granule
GO:0005125: cytokine activity
GO:0005149: interleukin-1 receptor binding
GO:0008083: growth factor activity
GO:0019904: protein domain specific binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4210: Apoptosis
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4623: Cytosolic DNA-sensing pathway
4640: Hematopoietic cell lineage
4940: Type I diabetes mellitus
5010: Alzheimer's disease
5020: Prion diseases
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5144: Malaria
5146: Amoebiasis
5323: Rheumatoid arthritis
5332: Graft-versus-host disease

PubMed abstracts associated with IL1B

PMID Title Tumor Value
1459694 Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. no no
1481722 The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. no no
1571831 Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells. no no
1932372 Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. no no
2521862 Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. no no
2786815 Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. no no
7835281 Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. no no
9664132 TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. no no
10896792 The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent. no no
17849429 Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. no no
22641358 Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. no no
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