General Information
Gene ID | 356 |
---|---|
Gene Symbol | FASLG |
Gene Name | Fas ligand (TNF superfamily, member 6) |
Gene Type | protein-coding |
Cytoband | 1q23 |
Ensembl ID | ENSG00000117560 |
#miR regulators | 6 |
Omim ID | 134638 211980 601859 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0006915: apoptotic process GO:0007165: signal transduction GO:0006351: transcription, DNA-dependent GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006925: inflammatory cell apoptotic process GO:0006955: immune response GO:0007267: cell-cell signaling GO:0070265: necrotic cell death GO:0008284: positive regulation of cell proliferation GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0016525: negative regulation of angiogenesis GO:0033554: cellular response to stress GO:0030644: cellular chloride ion homeostasis GO:0032496: response to lipopolysaccharide GO:0043065: positive regulation of apoptotic process GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043525: positive regulation of neuron apoptotic process GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway GO:0046666: retinal cell programmed cell death GO:0048388: endosomal lumen acidification GO:0070848: response to growth factor stimulus GO:0060554: activation of necroptosis of activated-T cells GO:0060555: activation of necroptosis by extracellular signals GO:0070231: T cell apoptotic process GO:0097190: apoptotic signaling pathway GO:2000353: positive regulation of endothelial cell apoptotic process GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005576: extracellular region GO:0005887: integral to plasma membrane GO:0005615: extracellular space GO:0005634: nucleus GO:0005901: caveola GO:0009897: external side of plasma membrane GO:0043202: lysosomal lumen GO:0048471: perinuclear region of cytoplasm GO:0060205: cytoplasmic membrane-bounded vesicle lumen GO:0070062: extracellular vesicular exosome GO:0005515: protein binding GO:0005102: receptor binding GO:0005125: cytokine activity GO:0005164: tumor necrosis factor receptor binding |
KEGG pathways |
4010: MAPK signaling pathway 4060: Cytokine-cytokine receptor interaction 4210: Apoptosis 4650: Natural killer cell mediated cytotoxicity 4722: Neurotrophin signaling pathway 4940: Type I diabetes mellitus 5142: Chagas disease (American trypanosomiasis) 5143: African trypanosomiasis 5200: Pathways in cancer 5320: Autoimmune thyroid disease 5330: Allograft rejection 5332: Graft-versus-host disease |
PMID | Title | Tumor | Value |
---|---|---|---|
9890264 | Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. | yes | no |
10977962 | Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. | yes | yes |
11093825 | Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. | no | no |
11358827 | Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. | no | yes |
14647441 | FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. | no | no |
14760101 | Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. | no | no |
15207713 | Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. | no | no |
17611696 | Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. | no | no |
18414033 | Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. | no | no |
20213411 | The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. | no | no |
20819644 | Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. | no | no |
21287529 | Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. | no | no |
21717192 | Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. | no | no |
22186140 | miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. | no | no |
title | all | all |