Results for FASLG

General Information

Gene ID 356
Gene Symbol FASLG
Gene Name Fas ligand (TNF superfamily, member 6)
Gene Type protein-coding
Cytoband 1q23
Ensembl ID ENSG00000117560
#miR regulators 6
Omim ID 134638 211980 601859
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006351: transcription, DNA-dependent
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925: inflammatory cell apoptotic process
GO:0006955: immune response
GO:0007267: cell-cell signaling
GO:0070265: necrotic cell death
GO:0008284: positive regulation of cell proliferation
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525: negative regulation of angiogenesis
GO:0033554: cellular response to stress
GO:0030644: cellular chloride ion homeostasis
GO:0032496: response to lipopolysaccharide
GO:0043065: positive regulation of apoptotic process
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043525: positive regulation of neuron apoptotic process
GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666: retinal cell programmed cell death
GO:0048388: endosomal lumen acidification
GO:0070848: response to growth factor stimulus
GO:0060554: activation of necroptosis of activated-T cells
GO:0060555: activation of necroptosis by extracellular signals
GO:0070231: T cell apoptotic process
GO:0097190: apoptotic signaling pathway
GO:2000353: positive regulation of endothelial cell apoptotic process
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0005901: caveola
GO:0009897: external side of plasma membrane
GO:0043202: lysosomal lumen
GO:0048471: perinuclear region of cytoplasm
GO:0060205: cytoplasmic membrane-bounded vesicle lumen
GO:0070062: extracellular vesicular exosome
GO:0005515: protein binding
GO:0005102: receptor binding
GO:0005125: cytokine activity
GO:0005164: tumor necrosis factor receptor binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4210: Apoptosis
4650: Natural killer cell mediated cytotoxicity
4722: Neurotrophin signaling pathway
4940: Type I diabetes mellitus
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5200: Pathways in cancer
5320: Autoimmune thyroid disease
5330: Allograft rejection
5332: Graft-versus-host disease

PubMed abstracts associated with FASLG

PMID Title Tumor Value
9890264 Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. yes no
10977962 Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. yes yes
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no
11358827 Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. no yes
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no
14760101 Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. no no
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no
17611696 Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. no no
18414033 Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. no no
20213411 The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. no no
20819644 Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. no no
21287529 Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. no no
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no
22186140 miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. no no
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