General Information
Gene ID | 3569 |
---|---|
Gene Symbol | IL6 |
Gene Name | interleukin 6 (interferon, beta 2) |
Gene Type | protein-coding |
Cytoband | 7p21 |
Ensembl ID | ENSG00000136244 |
#miR regulators | --- |
Omim ID | 108010 125853 147620 148000 222100 266600 604302 |
Gene ontology |
GO:0016049: cell growth GO:0001781: neutrophil apoptotic process GO:0002384: hepatic immune response GO:0002446: neutrophil mediated immunity GO:0002548: monocyte chemotaxis GO:0002675: positive regulation of acute inflammatory response GO:0002690: positive regulation of leukocyte chemotaxis GO:0006953: acute-phase response GO:0045454: cell redox homeostasis GO:0006469: negative regulation of protein kinase activity GO:0009612: response to mechanical stimulus GO:0006954: inflammatory response GO:0006959: humoral immune response GO:0007568: aging GO:0043066: negative regulation of apoptotic process GO:0050830: defense response to Gram-positive bacterium GO:0050829: defense response to Gram-negative bacterium GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008360: regulation of cell shape GO:0042493: response to drug GO:0009408: response to heat GO:0009409: response to cold GO:0010574: regulation of vascular endothelial growth factor production GO:0010888: negative regulation of lipid storage GO:0045727: positive regulation of translation GO:0045893: positive regulation of transcription, DNA-dependent GO:0046677: response to antibiotic GO:0019221: cytokine-mediated signaling pathway GO:0030168: platelet activation GO:0031000: response to caffeine GO:0031018: endocrine pancreas development GO:0031175: neuron projection development GO:0031667: response to nutrient levels GO:0032494: response to peptidoglycan GO:0032496: response to lipopolysaccharide GO:0032722: positive regulation of chemokine production GO:0032755: positive regulation of interleukin-6 production GO:0032868: response to insulin stimulus GO:0032966: negative regulation of collagen biosynthetic process GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0033160: positive regulation of protein import into nucleus, translocation GO:0042102: positive regulation of T cell proliferation GO:0042110: T cell activation GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042832: defense response to protozoan GO:0043065: positive regulation of apoptotic process GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043200: response to amino acid stimulus GO:0043410: positive regulation of MAPK cascade GO:0045079: negative regulation of chemokine biosynthetic process GO:0045188: regulation of circadian sleep/wake cycle, non-REM sleep GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0045599: negative regulation of fat cell differentiation GO:0045630: positive regulation of T-helper 2 cell differentiation GO:0045666: positive regulation of neuron differentiation GO:0045669: positive regulation of osteoblast differentiation GO:0045721: negative regulation of gluconeogenesis GO:0045740: positive regulation of DNA replication GO:0045765: regulation of angiogenesis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046427: positive regulation of JAK-STAT cascade GO:0046716: muscle cell cellular homeostasis GO:0046849: bone remodeling GO:0046888: negative regulation of hormone secretion GO:0048635: negative regulation of muscle organ development GO:0048661: positive regulation of smooth muscle cell proliferation GO:0050679: positive regulation of epithelial cell proliferation GO:0050710: negative regulation of cytokine secretion GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0050871: positive regulation of B cell activation GO:0051024: positive regulation of immunoglobulin secretion GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity GO:0051384: response to glucocorticoid stimulus GO:0051592: response to calcium ion GO:0051602: response to electrical stimulus GO:0051607: defense response to virus GO:0051897: positive regulation of protein kinase B signaling cascade GO:0051971: positive regulation of transmission of nerve impulse GO:0060445: branching involved in salivary gland morphogenesis GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis GO:0070091: glucagon secretion GO:0070102: interleukin-6-mediated signaling pathway GO:0070301: cellular response to hydrogen peroxide GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:1901215: negative regulation of neuron death GO:2000366: positive regulation of STAT protein import into nucleus GO:2000676: positive regulation of type B pancreatic cell apoptotic process GO:0005576: extracellular region GO:0005615: extracellular space GO:0005896: interleukin-6 receptor complex GO:0009897: external side of plasma membrane GO:0005125: cytokine activity GO:0005138: interleukin-6 receptor binding GO:0008083: growth factor activity |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4620: Toll-like receptor signaling pathway 4621: NOD-like receptor signaling pathway 4623: Cytosolic DNA-sensing pathway 4630: Jak-STAT signaling pathway 4640: Hematopoietic cell lineage 4672: Intestinal immune network for IgA production 5020: Prion diseases 5142: Chagas disease (American trypanosomiasis) 5143: African trypanosomiasis 5144: Malaria 5146: Amoebiasis 5200: Pathways in cancer 5323: Rheumatoid arthritis 5332: Graft-versus-host disease 5410: Hypertrophic cardiomyopathy (HCM) |
PMID | Title | Tumor | Value |
---|---|---|---|
9664132 | TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. | no | no |
10339667 | Expression of G1 phase regulators in MG-63 osteosarcoma cell line. | no | no |
11089884 | Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. | no | no |
11155789 | Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. | no | no |
11768200 | Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. | no | no |
11820362 | Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. | no | no |
12027404 | Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. | no | no |
12232677 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. | no | no |
14598359 | Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. | yes | yes |
15923123 | Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). | no | no |
16475708 | Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. | no | no |
17116726 | Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. | no | no |
17849429 | Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. | no | no |
22641358 | Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. | no | no |
22743617 | STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. | no | no |
22939995 | IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. | yes | no |
23219526 | Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. | no | no |
title | all | all |