Results for IL6

General Information

Gene ID 3569
Gene Symbol IL6
Gene Name interleukin 6 (interferon, beta 2)
Gene Type protein-coding
Cytoband 7p21
Ensembl ID ENSG00000136244
#miR regulators ---
Omim ID 108010 125853 147620 148000 222100 266600 604302
Gene ontology GO:0016049: cell growth
GO:0001781: neutrophil apoptotic process
GO:0002384: hepatic immune response
GO:0002446: neutrophil mediated immunity
GO:0002548: monocyte chemotaxis
GO:0002675: positive regulation of acute inflammatory response
GO:0002690: positive regulation of leukocyte chemotaxis
GO:0006953: acute-phase response
GO:0045454: cell redox homeostasis
GO:0006469: negative regulation of protein kinase activity
GO:0009612: response to mechanical stimulus
GO:0006954: inflammatory response
GO:0006959: humoral immune response
GO:0007568: aging
GO:0043066: negative regulation of apoptotic process
GO:0050830: defense response to Gram-positive bacterium
GO:0050829: defense response to Gram-negative bacterium
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0042493: response to drug
GO:0009408: response to heat
GO:0009409: response to cold
GO:0010574: regulation of vascular endothelial growth factor production
GO:0010888: negative regulation of lipid storage
GO:0045727: positive regulation of translation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0046677: response to antibiotic
GO:0019221: cytokine-mediated signaling pathway
GO:0030168: platelet activation
GO:0031000: response to caffeine
GO:0031018: endocrine pancreas development
GO:0031175: neuron projection development
GO:0031667: response to nutrient levels
GO:0032494: response to peptidoglycan
GO:0032496: response to lipopolysaccharide
GO:0032722: positive regulation of chemokine production
GO:0032755: positive regulation of interleukin-6 production
GO:0032868: response to insulin stimulus
GO:0032966: negative regulation of collagen biosynthetic process
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0033160: positive regulation of protein import into nucleus, translocation
GO:0042102: positive regulation of T cell proliferation
GO:0042110: T cell activation
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042832: defense response to protozoan
GO:0043065: positive regulation of apoptotic process
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200: response to amino acid stimulus
GO:0043410: positive regulation of MAPK cascade
GO:0045079: negative regulation of chemokine biosynthetic process
GO:0045188: regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045599: negative regulation of fat cell differentiation
GO:0045630: positive regulation of T-helper 2 cell differentiation
GO:0045666: positive regulation of neuron differentiation
GO:0045669: positive regulation of osteoblast differentiation
GO:0045721: negative regulation of gluconeogenesis
GO:0045740: positive regulation of DNA replication
GO:0045765: regulation of angiogenesis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046427: positive regulation of JAK-STAT cascade
GO:0046716: muscle cell cellular homeostasis
GO:0046849: bone remodeling
GO:0046888: negative regulation of hormone secretion
GO:0048635: negative regulation of muscle organ development
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050710: negative regulation of cytokine secretion
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050871: positive regulation of B cell activation
GO:0051024: positive regulation of immunoglobulin secretion
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384: response to glucocorticoid stimulus
GO:0051592: response to calcium ion
GO:0051602: response to electrical stimulus
GO:0051607: defense response to virus
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0051971: positive regulation of transmission of nerve impulse
GO:0060445: branching involved in salivary gland morphogenesis
GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091: glucagon secretion
GO:0070102: interleukin-6-mediated signaling pathway
GO:0070301: cellular response to hydrogen peroxide
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:1901215: negative regulation of neuron death
GO:2000366: positive regulation of STAT protein import into nucleus
GO:2000676: positive regulation of type B pancreatic cell apoptotic process
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005896: interleukin-6 receptor complex
GO:0009897: external side of plasma membrane
GO:0005125: cytokine activity
GO:0005138: interleukin-6 receptor binding
GO:0008083: growth factor activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4623: Cytosolic DNA-sensing pathway
4630: Jak-STAT signaling pathway
4640: Hematopoietic cell lineage
4672: Intestinal immune network for IgA production
5020: Prion diseases
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5144: Malaria
5146: Amoebiasis
5200: Pathways in cancer
5323: Rheumatoid arthritis
5332: Graft-versus-host disease
5410: Hypertrophic cardiomyopathy (HCM)

PubMed abstracts associated with IL6

PMID Title Tumor Value
9664132 TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. no no
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
11089884 Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. no no
11155789 Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. no no
11768200 Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. no no
11820362 Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. no no
12027404 Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. no no
12232677 Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. no no
14598359 Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. yes yes
15923123 Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). no no
16475708 Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17849429 Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. no no
22641358 Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. no no
22743617 STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. no no
22939995 IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. yes no
23219526 Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. no no
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