Results for IL6R

General Information

Gene ID 3570
Gene Symbol IL6R
Gene Name interleukin 6 receptor
Gene Type protein-coding
Cytoband 1q21
Ensembl ID ENSG00000160712
#miR regulators 12
Omim ID 147880 614689 614752
Gene ontology GO:0002384: hepatic immune response
GO:0002446: neutrophil mediated immunity
GO:0002548: monocyte chemotaxis
GO:0002690: positive regulation of leukocyte chemotaxis
GO:0006953: acute-phase response
GO:0050830: defense response to Gram-positive bacterium
GO:0050829: defense response to Gram-negative bacterium
GO:0008284: positive regulation of cell proliferation
GO:0010536: positive regulation of activation of Janus kinase activity
GO:0019221: cytokine-mediated signaling pathway
GO:0031018: endocrine pancreas development
GO:0032717: negative regulation of interleukin-8 production
GO:0032722: positive regulation of chemokine production
GO:0032755: positive regulation of interleukin-6 production
GO:0032966: negative regulation of collagen biosynthetic process
GO:0034097: response to cytokine stimulus
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410: positive regulation of MAPK cascade
GO:0045669: positive regulation of osteoblast differentiation
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0070102: interleukin-6-mediated signaling pathway
GO:0070120: ciliary neurotrophic factor-mediated signaling pathway
GO:0097191: extrinsic apoptotic signaling pathway
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005896: interleukin-6 receptor complex
GO:0009986: cell surface
GO:0016323: basolateral plasma membrane
GO:0016324: apical plasma membrane
GO:0005515: protein binding
GO:0004897: ciliary neurotrophic factor receptor activity
GO:0004915: interleukin-6 receptor activity
GO:0005138: interleukin-6 receptor binding
GO:0019899: enzyme binding
GO:0019981: interleukin-6 binding
GO:0042803: protein homodimerization activity
GO:0070119: ciliary neurotrophic factor binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4630: Jak-STAT signaling pathway
4640: Hematopoietic cell lineage

PubMed abstracts associated with IL6R

PMID Title Tumor Value
11089884 Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. no no
title all all