General Information
| Gene ID | 3576 |
|---|---|
| Gene Symbol | IL8 |
| Gene Name | interleukin 8 |
| Gene Type | protein-coding |
| Cytoband | 4q13-q21 |
| Ensembl ID | ENSG00000169429 |
| #miR regulators | 8 |
| Omim ID | 146930 |
| Gene ontology |
GO:0001525: angiogenesis GO:0002237: response to molecule of bacterial origin GO:0007165: signal transduction GO:0035556: intracellular signal transduction GO:0006928: cellular component movement GO:0006954: inflammatory response GO:0006955: immune response GO:0006987: activation of signaling protein activity involved in unfolded protein response GO:0007050: cell cycle arrest GO:0007186: G-protein coupled receptor signaling pathway GO:0019722: calcium-mediated signaling GO:0008285: negative regulation of cell proliferation GO:0045744: negative regulation of G-protein coupled receptor protein signaling pathway GO:0030155: regulation of cell adhesion GO:0030593: neutrophil chemotaxis GO:0030968: endoplasmic reticulum unfolded protein response GO:0031623: receptor internalization GO:0034976: response to endoplasmic reticulum stress GO:0042119: neutrophil activation GO:0044267: cellular protein metabolic process GO:0044344: cellular response to fibroblast growth factor stimulus GO:0045091: regulation of retroviral genome replication GO:0048566: embryonic digestive tract development GO:0050930: induction of positive chemotaxis GO:0071222: cellular response to lipopolysaccharide GO:0071347: cellular response to interleukin-1 GO:0071356: cellular response to tumor necrosis factor GO:0090023: positive regulation of neutrophil chemotaxis GO:0005576: extracellular region GO:0005615: extracellular space GO:0005515: protein binding GO:0005153: interleukin-8 receptor binding GO:0008009: chemokine activity |
| KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4062: Chemokine signaling pathway 4620: Toll-like receptor signaling pathway 4621: NOD-like receptor signaling pathway 4622: RIG-I-like receptor signaling pathway 5120: Epithelial cell signaling in Helicobacter pylori infection 5131: Shigellosis 5142: Chagas disease (American trypanosomiasis) 5144: Malaria 5146: Amoebiasis 5160: Hepatitis C 5200: Pathways in cancer 5219: Bladder cancer 5323: Rheumatoid arthritis |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 14598359 | Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. | yes | yes |
| 18510171 | Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. | no | no |
| 22641358 | Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. | no | no |
| title | all | all |