Results for IL12A

General Information

Gene ID 3592
Gene Symbol IL12A
Gene Name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Gene Type protein-coding
Cytoband 3q25.33
Ensembl ID ENSG00000168811
#miR regulators 3
Omim ID 161560
Gene ontology GO:0001916: positive regulation of T cell mediated cytotoxicity
GO:0002860: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0009615: response to virus
GO:0006955: immune response
GO:0007050: cell cycle arrest
GO:0050830: defense response to Gram-positive bacterium
GO:0010224: response to UV-B
GO:0016477: cell migration
GO:0032496: response to lipopolysaccharide
GO:0032700: negative regulation of interleukin-17 production
GO:0032729: positive regulation of interferon-gamma production
GO:0032816: positive regulation of natural killer cell activation
GO:0034393: positive regulation of smooth muscle cell apoptotic process
GO:0042102: positive regulation of T cell proliferation
GO:0042520: positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042832: defense response to protozoan
GO:0045582: positive regulation of T cell differentiation
GO:0045785: positive regulation of cell adhesion
GO:0045954: positive regulation of natural killer cell mediated cytotoxicity
GO:0048662: negative regulation of smooth muscle cell proliferation
GO:0050671: positive regulation of lymphocyte proliferation
GO:0051135: positive regulation of NK T cell activation
GO:0097191: extrinsic apoptotic signaling pathway
GO:0005615: extracellular space
GO:0005737: cytoplasm
GO:0043514: interleukin-12 complex
GO:0005515: protein binding
GO:0005125: cytokine activity
GO:0005143: interleukin-12 receptor binding
GO:0008083: growth factor activity
GO:0042163: interleukin-12 beta subunit binding
GO:0045513: interleukin-27 binding
GO:0046982: protein heterodimerization activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4620: Toll-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4630: Jak-STAT signaling pathway
4940: Type I diabetes mellitus
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5144: Malaria
5145: Toxoplasmosis
5146: Amoebiasis
5330: Allograft rejection

PubMed abstracts associated with IL12A

PMID Title Tumor Value
11358827 Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. no yes
12014674 Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. no no
14660053 Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. no no
14760101 Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. no no
16380506 Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. no no
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