Results for IL18

General Information

Gene ID 3606
Gene Symbol IL18
Gene Name interleukin 18 (interferon-gamma-inducing factor)
Gene Type protein-coding
Cytoband 11q22.2-q22.3
Ensembl ID ENSG00000150782
#miR regulators 1
Omim ID 600953
Gene ontology GO:0000165: MAPK cascade
GO:0001525: angiogenesis
GO:0001649: osteoblast differentiation
GO:0001666: response to hypoxia
GO:0006954: inflammatory response
GO:0006955: immune response
GO:0007267: cell-cell signaling
GO:0009314: response to radiation
GO:0009409: response to cold
GO:0010628: positive regulation of gene expression
GO:0071260: cellular response to mechanical stimulus
GO:0030101: natural killer cell activation
GO:0030155: regulation of cell adhesion
GO:0030324: lung development
GO:0030431: sleep
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0032722: positive regulation of chemokine production
GO:0032725: positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729: positive regulation of interferon-gamma production
GO:0032731: positive regulation of interleukin-1 beta production
GO:0032740: positive regulation of interleukin-17 production
GO:0032757: positive regulation of interleukin-8 production
GO:0032760: positive regulation of tumor necrosis factor production
GO:0032819: positive regulation of natural killer cell proliferation
GO:0032930: positive regulation of superoxide anion generation
GO:0032967: positive regulation of collagen biosynthetic process
GO:0034105: positive regulation of tissue remodeling
GO:0042033: chemokine biosynthetic process
GO:0042088: T-helper 1 type immune response
GO:0042092: type 2 immune response
GO:0042094: interleukin-2 biosynthetic process
GO:0042095: interferon-gamma biosynthetic process
GO:0042104: positive regulation of activated T cell proliferation
GO:0042231: interleukin-13 biosynthetic process
GO:0042253: granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0042346: positive regulation of NF-kappaB import into nucleus
GO:0043117: positive regulation of vascular permeability
GO:0043525: positive regulation of neuron apoptotic process
GO:0048546: digestive tract morphogenesis
GO:0050729: positive regulation of inflammatory response
GO:0050966: detection of mechanical stimulus involved in sensory perception of pain
GO:0051142: positive regulation of NK T cell proliferation
GO:0055093: response to hyperoxia
GO:0070301: cellular response to hydrogen peroxide
GO:0071320: cellular response to cAMP
GO:0071346: cellular response to interferon-gamma
GO:0071356: cellular response to tumor necrosis factor
GO:0071374: cellular response to parathyroid hormone stimulus
GO:0071375: cellular response to peptide hormone stimulus
GO:0071407: cellular response to organic cyclic compound
GO:2000256: positive regulation of male germ cell proliferation
GO:2000504: positive regulation of blood vessel remodeling
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005615: extracellular space
GO:0016324: apical plasma membrane
GO:0005125: cytokine activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4621: NOD-like receptor signaling pathway
4623: Cytosolic DNA-sensing pathway
5143: African trypanosomiasis
5144: Malaria
5323: Rheumatoid arthritis

PubMed abstracts associated with IL18

PMID Title Tumor Value
12014674 Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. no no
14660053 Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. no no
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