General Information
Gene ID | 3611 |
---|---|
Gene Symbol | ILK |
Gene Name | integrin-linked kinase |
Gene Type | protein-coding |
Cytoband | 11p15.4 |
Ensembl ID | ENSG00000166333 |
#miR regulators | 1 |
Omim ID | 602366 |
Gene ontology |
GO:0001658: branching involved in ureteric bud morphogenesis GO:0001954: positive regulation of cell-matrix adhesion GO:0006468: protein phosphorylation GO:0006469: negative regulation of protein kinase activity GO:0007050: cell cycle arrest GO:0007160: cell-matrix adhesion GO:0007229: integrin-mediated signaling pathway GO:0007569: cell aging GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0010667: negative regulation of cardiac muscle cell apoptotic process GO:0014912: negative regulation of smooth muscle cell migration GO:0045893: positive regulation of transcription, DNA-dependent GO:0018105: peptidyl-serine phosphorylation GO:0021675: nerve development GO:0022011: myelination in peripheral nervous system GO:0030335: positive regulation of cell migration GO:0030513: positive regulation of BMP signaling pathway GO:0032288: myelin assembly GO:0032956: regulation of actin cytoskeleton organization GO:0034329: cell junction assembly GO:0034446: substrate adhesion-dependent cell spreading GO:0042327: positive regulation of phosphorylation GO:0043206: extracellular fibril organization GO:0043406: positive regulation of MAP kinase activity GO:0043491: protein kinase B signaling cascade GO:0043524: negative regulation of neuron apoptotic process GO:0045197: establishment or maintenance of epithelial cell apical/basal polarity GO:0045663: positive regulation of myoblast differentiation GO:0045669: positive regulation of osteoblast differentiation GO:0045773: positive regulation of axon extension GO:0048662: negative regulation of smooth muscle cell proliferation GO:0048812: neuron projection morphogenesis GO:0050775: positive regulation of dendrite morphogenesis GO:0051291: protein heterooligomerization GO:0051897: positive regulation of protein kinase B signaling cascade GO:0090263: positive regulation of canonical Wnt receptor signaling pathway GO:0005886: plasma membrane GO:0005829: cytosol GO:0005737: cytoplasm GO:0005911: cell-cell junction GO:0005925: focal adhesion GO:0030017: sarcomere GO:0030027: lamellipodium GO:0043025: neuronal cell body GO:0043034: costamere GO:0043195: terminal bouton GO:0043198: dendritic shaft GO:0043234: protein complex GO:0005515: protein binding GO:0004674: protein serine/threonine kinase activity GO:0004871: signal transducer activity GO:0005178: integrin binding GO:0005524: ATP binding GO:0017124: SH3 domain binding GO:0019901: protein kinase binding |
KEGG pathways |
3320: PPAR signaling pathway 4510: Focal adhesion 5100: Bacterial invasion of epithelial cells 5213: Endometrial cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
21145881 | Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. | no | no |
22939995 | IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. | yes | no |
title | all | all |