Results for IRS1

General Information

Gene ID 3667
Gene Symbol IRS1
Gene Name insulin receptor substrate 1
Gene Type protein-coding
Cytoband 2q36
Ensembl ID ENSG00000169047
#miR regulators 19
Omim ID 125853 147545
Gene ontology GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0007165: signal transduction
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0008284: positive regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010468: regulation of gene expression
GO:0010907: positive regulation of glucose metabolic process
GO:0014065: phosphatidylinositol 3-kinase cascade
GO:0016042: lipid catabolic process
GO:0046326: positive regulation of glucose import
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030335: positive regulation of cell migration
GO:0030879: mammary gland development
GO:0032000: positive regulation of fatty acid beta-oxidation
GO:0032868: response to insulin stimulus
GO:0032869: cellular response to insulin stimulus
GO:0034504: protein localization to nucleus
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042593: glucose homeostasis
GO:0043434: response to peptide hormone stimulus
GO:0043491: protein kinase B signaling cascade
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045725: positive regulation of glycogen biosynthetic process
GO:0046627: negative regulation of insulin receptor signaling pathway
GO:0046628: positive regulation of insulin receptor signaling pathway
GO:0046676: negative regulation of insulin secretion
GO:0048009: insulin-like growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway
GO:2001275: positive regulation of glucose import in response to insulin stimulus
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0043231: intracellular membrane-bounded organelle
GO:0005899: insulin receptor complex
GO:0005901: caveola
GO:0005515: protein binding
GO:0004871: signal transducer activity
GO:0005068: transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080: protein kinase C binding
GO:0005158: insulin receptor binding
GO:0005159: insulin-like growth factor receptor binding
GO:0005543: phospholipid binding
GO:0042169: SH2 domain binding
GO:0043548: phosphatidylinositol 3-kinase binding
KEGG pathways 4722: Neurotrophin signaling pathway
4910: Insulin signaling pathway
4920: Adipocytokine signaling pathway
4930: Type II diabetes mellitus
4960: Aldosterone-regulated sodium reabsorption

PubMed abstracts associated with IRS1

PMID Title Tumor Value
9492043 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. no no
10453987 Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. no no
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