General Information
Gene ID | 3673 |
---|---|
Gene Symbol | ITGA2 |
Gene Name | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
Gene Type | protein-coding |
Cytoband | 5q11.2 |
Ensembl ID | ENSG00000164171 |
#miR regulators | 19 |
Omim ID | 192974 614200 |
Gene ontology |
GO:0007596: blood coagulation GO:0007155: cell adhesion GO:0007160: cell-matrix adhesion GO:0007229: integrin-mediated signaling pathway GO:0009887: organ morphogenesis GO:0007411: axon guidance GO:0019048: modulation by virus of host morphology or physiology GO:0030198: extracellular matrix organization GO:0005886: plasma membrane GO:0008305: integrin complex GO:0009897: external side of plasma membrane GO:0009986: cell surface GO:0045178: basal part of cell GO:0005515: protein binding GO:0001618: virus receptor activity GO:0046872: metal ion binding GO:0005518: collagen binding |
KEGG pathways |
4145: Phagosome 4510: Focal adhesion 4512: ECM-receptor interaction 4640: Hematopoietic cell lineage 4810: Regulation of actin cytoskeleton 5200: Pathways in cancer 5222: Small cell lung cancer 5410: Hypertrophic cardiomyopathy (HCM) 5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5414: Dilated cardiomyopathy |
PMID | Title | Tumor | Value |
---|---|---|---|
8288590 | Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. | no | no |
9052985 | Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. | no | no |
11319838 | Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. | no | no |
15746965 | Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. | no | no |
16798617 | Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. | no | no |
title | all | all |