Results for ITGA2

General Information

Gene ID 3673
Gene Symbol ITGA2
Gene Name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Gene Type protein-coding
Cytoband 5q11.2
Ensembl ID ENSG00000164171
#miR regulators 19
Omim ID 192974 614200
Gene ontology GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007160: cell-matrix adhesion
GO:0007229: integrin-mediated signaling pathway
GO:0009887: organ morphogenesis
GO:0007411: axon guidance
GO:0019048: modulation by virus of host morphology or physiology
GO:0030198: extracellular matrix organization
GO:0005886: plasma membrane
GO:0008305: integrin complex
GO:0009897: external side of plasma membrane
GO:0009986: cell surface
GO:0045178: basal part of cell
GO:0005515: protein binding
GO:0001618: virus receptor activity
GO:0046872: metal ion binding
GO:0005518: collagen binding
KEGG pathways 4145: Phagosome
4510: Focal adhesion
4512: ECM-receptor interaction
4640: Hematopoietic cell lineage
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5222: Small cell lung cancer
5410: Hypertrophic cardiomyopathy (HCM)
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
5414: Dilated cardiomyopathy

PubMed abstracts associated with ITGA2

PMID Title Tumor Value
8288590 Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. no no
9052985 Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. no no
11319838 Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. no no
15746965 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. no no
16798617 Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. no no
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