Results for ITGA5

General Information

Gene ID 3678
Gene Symbol ITGA5
Gene Name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Gene Type protein-coding
Cytoband 12q11-q13
Ensembl ID ENSG00000161638
#miR regulators 6
Omim ID 135620
Gene ontology GO:0001525: angiogenesis
GO:0007157: heterophilic cell-cell adhesion
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007044: cell-substrate junction assembly
GO:0007159: leukocyte cell-cell adhesion
GO:0007229: integrin-mediated signaling pathway
GO:0007411: axon guidance
GO:0007613: memory
GO:0019048: modulation by virus of host morphology or physiology
GO:0030198: extracellular matrix organization
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0033631: cell-cell adhesion mediated by integrin
GO:0035313: wound healing, spreading of epidermal cells
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900: leukocyte migration
GO:2000811: negative regulation of anoikis
GO:0005886: plasma membrane
GO:0001726: ruffle
GO:0008305: integrin complex
GO:0005911: cell-cell junction
GO:0005925: focal adhesion
GO:0009897: external side of plasma membrane
GO:0032587: ruffle membrane
GO:0045202: synapse
GO:0071062: alphav-beta3 integrin-vitronectin complex
GO:0005515: protein binding
GO:0005161: platelet-derived growth factor receptor binding
GO:0005178: integrin binding
GO:0046872: metal ion binding
GO:0043184: vascular endothelial growth factor receptor 2 binding
KEGG pathways 4145: Phagosome
4510: Focal adhesion
4512: ECM-receptor interaction
4640: Hematopoietic cell lineage
4810: Regulation of actin cytoskeleton
5100: Bacterial invasion of epithelial cells
5131: Shigellosis
5410: Hypertrophic cardiomyopathy (HCM)
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
5414: Dilated cardiomyopathy

PubMed abstracts associated with ITGA5

PMID Title Tumor Value
2600089 Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. no no
11319838 Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. no no
12054686 Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. no no
16035619 Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. no no
16798617 Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. no no
18854653 Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. yes yes
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no
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