General Information
Gene ID | 3685 |
---|---|
Gene Symbol | ITGAV |
Gene Name | integrin, alpha V |
Gene Type | protein-coding |
Cytoband | 2q31-q32 |
Ensembl ID | ENSG00000138448 |
#miR regulators | 14 |
Omim ID | 193210 |
Gene ontology |
GO:0001525: angiogenesis GO:0002474: antigen processing and presentation of peptide antigen via MHC class I GO:0002479: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0007596: blood coagulation GO:0007155: cell adhesion GO:0007160: cell-matrix adhesion GO:0007229: integrin-mediated signaling pathway GO:0007411: axon guidance GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0010745: negative regulation of macrophage derived foam cell differentiation GO:0010888: negative regulation of lipid storage GO:0019048: modulation by virus of host morphology or physiology GO:0046718: viral entry into host cell GO:0030198: extracellular matrix organization GO:0030335: positive regulation of cell migration GO:0032369: negative regulation of lipid transport GO:0033690: positive regulation of osteoblast proliferation GO:0042590: antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0043277: apoptotic cell clearance GO:0045715: negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045785: positive regulation of cell adhesion GO:0050748: negative regulation of lipoprotein metabolic process GO:0050764: regulation of phagocytosis GO:0050900: leukocyte migration GO:0052066: entry of symbiont into host cell by promotion of host phagocytosis GO:0070371: ERK1 and ERK2 cascade GO:0070588: calcium ion transmembrane transport GO:0097192: extrinsic apoptotic signaling pathway in absence of ligand GO:2000425: regulation of apoptotic cell clearance GO:2000536: negative regulation of entry of bacterium into host cell GO:2001237: negative regulation of extrinsic apoptotic signaling pathway GO:0005886: plasma membrane GO:0016020: membrane GO:0005887: integral to plasma membrane GO:0008305: integrin complex GO:0009897: external side of plasma membrane GO:0009986: cell surface GO:0035867: alphav-beta3 integrin-IGF-1-IGF1R complex GO:0045335: phagocytic vesicle GO:0005515: protein binding GO:0001618: virus receptor activity GO:0001846: opsonin binding GO:0005080: protein kinase C binding GO:0005245: voltage-gated calcium channel activity GO:0046872: metal ion binding GO:0050431: transforming growth factor beta binding GO:0031994: insulin-like growth factor I binding |
KEGG pathways |
4145: Phagosome 4510: Focal adhesion 4512: ECM-receptor interaction 4514: Cell adhesion molecules (CAMs) 4810: Regulation of actin cytoskeleton 5200: Pathways in cancer 5222: Small cell lung cancer 5410: Hypertrophic cardiomyopathy (HCM) 5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5414: Dilated cardiomyopathy |
PMID | Title | Tumor | Value |
---|---|---|---|
18445685 | PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. | yes | no |
20798956 | TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis. | no | no |
21145881 | Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. | no | no |
title | all | all |