Results for ITGAV

General Information

Gene ID 3685
Gene Symbol ITGAV
Gene Name integrin, alpha V
Gene Type protein-coding
Cytoband 2q31-q32
Ensembl ID ENSG00000138448
#miR regulators 14
Omim ID 193210
Gene ontology GO:0001525: angiogenesis
GO:0002474: antigen processing and presentation of peptide antigen via MHC class I
GO:0002479: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007160: cell-matrix adhesion
GO:0007229: integrin-mediated signaling pathway
GO:0007411: axon guidance
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0010745: negative regulation of macrophage derived foam cell differentiation
GO:0010888: negative regulation of lipid storage
GO:0019048: modulation by virus of host morphology or physiology
GO:0046718: viral entry into host cell
GO:0030198: extracellular matrix organization
GO:0030335: positive regulation of cell migration
GO:0032369: negative regulation of lipid transport
GO:0033690: positive regulation of osteoblast proliferation
GO:0042590: antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043277: apoptotic cell clearance
GO:0045715: negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785: positive regulation of cell adhesion
GO:0050748: negative regulation of lipoprotein metabolic process
GO:0050764: regulation of phagocytosis
GO:0050900: leukocyte migration
GO:0052066: entry of symbiont into host cell by promotion of host phagocytosis
GO:0070371: ERK1 and ERK2 cascade
GO:0070588: calcium ion transmembrane transport
GO:0097192: extrinsic apoptotic signaling pathway in absence of ligand
GO:2000425: regulation of apoptotic cell clearance
GO:2000536: negative regulation of entry of bacterium into host cell
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:0005886: plasma membrane
GO:0016020: membrane
GO:0005887: integral to plasma membrane
GO:0008305: integrin complex
GO:0009897: external side of plasma membrane
GO:0009986: cell surface
GO:0035867: alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0045335: phagocytic vesicle
GO:0005515: protein binding
GO:0001618: virus receptor activity
GO:0001846: opsonin binding
GO:0005080: protein kinase C binding
GO:0005245: voltage-gated calcium channel activity
GO:0046872: metal ion binding
GO:0050431: transforming growth factor beta binding
GO:0031994: insulin-like growth factor I binding
KEGG pathways 4145: Phagosome
4510: Focal adhesion
4512: ECM-receptor interaction
4514: Cell adhesion molecules (CAMs)
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5222: Small cell lung cancer
5410: Hypertrophic cardiomyopathy (HCM)
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
5414: Dilated cardiomyopathy

PubMed abstracts associated with ITGAV

PMID Title Tumor Value
18445685 PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. yes no
20798956 TIMP-1 interaction with ?v?3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-?-induced apoptosis. no no
21145881 Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves ?v?5 integrin, ILK and AP-1-dependent pathways. no no
title all all