Results for ITGB1

General Information

Gene ID 3688
Gene Symbol ITGB1
Gene Name integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Gene Type protein-coding
Cytoband 10p11.2
Ensembl ID ENSG00000150093
#miR regulators 8
Omim ID 135630
Gene ontology GO:0000082: G1/S transition of mitotic cell cycle
GO:0001701: in utero embryonic development
GO:0001708: cell fate specification
GO:0001894: tissue homeostasis
GO:0002042: cell migration involved in sprouting angiogenesis
GO:0051726: regulation of cell cycle
GO:0007596: blood coagulation
GO:0006874: cellular calcium ion homeostasis
GO:0006968: cellular defense response
GO:0007156: homophilic cell adhesion
GO:0007159: leukocyte cell-cell adhesion
GO:0007160: cell-matrix adhesion
GO:0007161: calcium-independent cell-matrix adhesion
GO:0007229: integrin-mediated signaling pathway
GO:0007411: axon guidance
GO:0008277: regulation of G-protein coupled receptor protein signaling pathway
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008354: germ cell migration
GO:0042493: response to drug
GO:0010811: positive regulation of cell-substrate adhesion
GO:0010976: positive regulation of neuron projection development
GO:0014823: response to activity
GO:0016477: cell migration
GO:0019048: modulation by virus of host morphology or physiology
GO:0071260: cellular response to mechanical stimulus
GO:0030183: B cell differentiation
GO:0030198: extracellular matrix organization
GO:0030335: positive regulation of cell migration
GO:0031345: negative regulation of cell projection organization
GO:0032594: protein transport within lipid bilayer
GO:0033631: cell-cell adhesion mediated by integrin
GO:0034329: cell junction assembly
GO:0034698: response to gonadotropin stimulus
GO:0043065: positive regulation of apoptotic process
GO:0043410: positive regulation of MAPK cascade
GO:0045214: sarcomere organization
GO:0045665: negative regulation of neuron differentiation
GO:0045666: positive regulation of neuron differentiation
GO:0045807: positive regulation of endocytosis
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776: regulation of immune response
GO:0050900: leukocyte migration
GO:0055007: cardiac muscle cell differentiation
GO:0060135: maternal process involved in female pregnancy
GO:0070830: tight junction assembly
GO:0071305: cellular response to vitamin D
GO:0071479: cellular response to ionizing radiation
GO:0071559: response to transforming growth factor beta stimulus
GO:2000811: negative regulation of anoikis
GO:0005886: plasma membrane
GO:0001669: acrosomal vesicle
GO:0001726: ruffle
GO:0005604: basement membrane
GO:0008305: integrin complex
GO:0005737: cytoplasm
GO:0005925: focal adhesion
GO:0009897: external side of plasma membrane
GO:0009986: cell surface
GO:0014704: intercalated disc
GO:0030027: lamellipodium
GO:0030056: hemidesmosome
GO:0030175: filopodium
GO:0031594: neuromuscular junction
GO:0032154: cleavage furrow
GO:0032587: ruffle membrane
GO:0034667: alpha3-beta1 integrin complex
GO:0034678: alpha8-beta1 integrin complex
GO:0034679: alpha9-beta1 integrin complex
GO:0035748: myelin sheath abaxonal region
GO:0042383: sarcolemma
GO:0042470: melanosome
GO:0045121: membrane raft
GO:0055037: recycling endosome
GO:0005515: protein binding
GO:0001618: virus receptor activity
GO:0001948: glycoprotein binding
GO:0001968: fibronectin binding
GO:0002020: protease binding
GO:0003779: actin binding
GO:0005178: integrin binding
GO:0046872: metal ion binding
GO:0005518: collagen binding
GO:0019901: protein kinase binding
GO:0019904: protein domain specific binding
GO:0042277: peptide binding
GO:0043236: laminin binding
GO:0046982: protein heterodimerization activity
GO:0051393: alpha-actinin binding
KEGG pathways 4145: Phagosome
4360: Axon guidance
4510: Focal adhesion
4512: ECM-receptor interaction
4514: Cell adhesion molecules (CAMs)
4670: Leukocyte transendothelial migration
4810: Regulation of actin cytoskeleton
5100: Bacterial invasion of epithelial cells
5130: Pathogenic Escherichia coli infection
5131: Shigellosis
5140: Leishmaniasis
5145: Toxoplasmosis
5200: Pathways in cancer
5222: Small cell lung cancer
5410: Hypertrophic cardiomyopathy (HCM)
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
5414: Dilated cardiomyopathy

PubMed abstracts associated with ITGB1

PMID Title Tumor Value
1281143 VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. no no
2521862 Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. no no
2600089 Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. no no
2786815 Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. no no
7541624 The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells. no no
8288590 Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. no no
9052985 Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. no no
11319838 Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. no no
12616540 Alpha 4 integrin increases anoikis of human osteosarcoma cells. yes no
15746965 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. no no
16878156 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. no no
18048360 Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. no no
21149578 Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. no no
21421073 Lumican regulates osteosarcoma cell adhesion by modulating TGF?2 activity. no no
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