General Information
Gene ID | 3688 |
---|---|
Gene Symbol | ITGB1 |
Gene Name | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
Gene Type | protein-coding |
Cytoband | 10p11.2 |
Ensembl ID | ENSG00000150093 |
#miR regulators | 8 |
Omim ID | 135630 |
Gene ontology |
GO:0000082: G1/S transition of mitotic cell cycle GO:0001701: in utero embryonic development GO:0001708: cell fate specification GO:0001894: tissue homeostasis GO:0002042: cell migration involved in sprouting angiogenesis GO:0051726: regulation of cell cycle GO:0007596: blood coagulation GO:0006874: cellular calcium ion homeostasis GO:0006968: cellular defense response GO:0007156: homophilic cell adhesion GO:0007159: leukocyte cell-cell adhesion GO:0007160: cell-matrix adhesion GO:0007161: calcium-independent cell-matrix adhesion GO:0007229: integrin-mediated signaling pathway GO:0007411: axon guidance GO:0008277: regulation of G-protein coupled receptor protein signaling pathway GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008354: germ cell migration GO:0042493: response to drug GO:0010811: positive regulation of cell-substrate adhesion GO:0010976: positive regulation of neuron projection development GO:0014823: response to activity GO:0016477: cell migration GO:0019048: modulation by virus of host morphology or physiology GO:0071260: cellular response to mechanical stimulus GO:0030183: B cell differentiation GO:0030198: extracellular matrix organization GO:0030335: positive regulation of cell migration GO:0031345: negative regulation of cell projection organization GO:0032594: protein transport within lipid bilayer GO:0033631: cell-cell adhesion mediated by integrin GO:0034329: cell junction assembly GO:0034698: response to gonadotropin stimulus GO:0043065: positive regulation of apoptotic process GO:0043410: positive regulation of MAPK cascade GO:0045214: sarcomere organization GO:0045665: negative regulation of neuron differentiation GO:0045666: positive regulation of neuron differentiation GO:0045807: positive regulation of endocytosis GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0050776: regulation of immune response GO:0050900: leukocyte migration GO:0055007: cardiac muscle cell differentiation GO:0060135: maternal process involved in female pregnancy GO:0070830: tight junction assembly GO:0071305: cellular response to vitamin D GO:0071479: cellular response to ionizing radiation GO:0071559: response to transforming growth factor beta stimulus GO:2000811: negative regulation of anoikis GO:0005886: plasma membrane GO:0001669: acrosomal vesicle GO:0001726: ruffle GO:0005604: basement membrane GO:0008305: integrin complex GO:0005737: cytoplasm GO:0005925: focal adhesion GO:0009897: external side of plasma membrane GO:0009986: cell surface GO:0014704: intercalated disc GO:0030027: lamellipodium GO:0030056: hemidesmosome GO:0030175: filopodium GO:0031594: neuromuscular junction GO:0032154: cleavage furrow GO:0032587: ruffle membrane GO:0034667: alpha3-beta1 integrin complex GO:0034678: alpha8-beta1 integrin complex GO:0034679: alpha9-beta1 integrin complex GO:0035748: myelin sheath abaxonal region GO:0042383: sarcolemma GO:0042470: melanosome GO:0045121: membrane raft GO:0055037: recycling endosome GO:0005515: protein binding GO:0001618: virus receptor activity GO:0001948: glycoprotein binding GO:0001968: fibronectin binding GO:0002020: protease binding GO:0003779: actin binding GO:0005178: integrin binding GO:0046872: metal ion binding GO:0005518: collagen binding GO:0019901: protein kinase binding GO:0019904: protein domain specific binding GO:0042277: peptide binding GO:0043236: laminin binding GO:0046982: protein heterodimerization activity GO:0051393: alpha-actinin binding |
KEGG pathways |
4145: Phagosome 4360: Axon guidance 4510: Focal adhesion 4512: ECM-receptor interaction 4514: Cell adhesion molecules (CAMs) 4670: Leukocyte transendothelial migration 4810: Regulation of actin cytoskeleton 5100: Bacterial invasion of epithelial cells 5130: Pathogenic Escherichia coli infection 5131: Shigellosis 5140: Leishmaniasis 5145: Toxoplasmosis 5200: Pathways in cancer 5222: Small cell lung cancer 5410: Hypertrophic cardiomyopathy (HCM) 5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5414: Dilated cardiomyopathy |
PMID | Title | Tumor | Value |
---|---|---|---|
1281143 | VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. | no | no |
2521862 | Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. | no | no |
2600089 | Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. | no | no |
2786815 | Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. | no | no |
7541624 | The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells. | no | no |
8288590 | Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. | no | no |
9052985 | Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. | no | no |
11319838 | Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. | no | no |
12616540 | Alpha 4 integrin increases anoikis of human osteosarcoma cells. | yes | no |
15746965 | Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. | no | no |
16878156 | Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. | no | no |
18048360 | Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. | no | no |
21149578 | Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. | no | no |
21421073 | Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity. | no | no |
title | all | all |