Results for ITGB3

General Information

Gene ID 3690
Gene Symbol ITGB3
Gene Name integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Gene Type protein-coding
Cytoband 17q21.32
Ensembl ID ENSG00000259207
#miR regulators 9
Omim ID 173470 187800 273800 608446
Gene ontology GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002576: platelet degranulation
GO:0006457: protein folding
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007044: cell-substrate junction assembly
GO:0007160: cell-matrix adhesion
GO:0007229: integrin-mediated signaling pathway
GO:0007411: axon guidance
GO:0010595: positive regulation of endothelial cell migration
GO:0010745: negative regulation of macrophage derived foam cell differentiation
GO:0010888: negative regulation of lipid storage
GO:0014909: smooth muscle cell migration
GO:0019048: modulation by virus of host morphology or physiology
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032147: activation of protein kinase activity
GO:0032369: negative regulation of lipid transport
GO:0035295: tube development
GO:0042060: wound healing
GO:0045124: regulation of bone resorption
GO:0045715: negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748: negative regulation of lipoprotein metabolic process
GO:0050900: leukocyte migration
GO:0060055: angiogenesis involved in wound healing
GO:0070527: platelet aggregation
GO:0005886: plasma membrane
GO:0005887: integral to plasma membrane
GO:0008305: integrin complex
GO:0005634: nucleus
GO:0005925: focal adhesion
GO:0031092: platelet alpha granule membrane
GO:0031258: lamellipodium membrane
GO:0042470: melanosome
GO:0071062: alphav-beta3 integrin-vitronectin complex
GO:0003756: protein disulfide isomerase activity
GO:0005515: protein binding
GO:0050839: cell adhesion molecule binding
GO:0004872: receptor activity
GO:0005161: platelet-derived growth factor receptor binding
GO:0042802: identical protein binding
GO:0043184: vascular endothelial growth factor receptor 2 binding
KEGG pathways 4145: Phagosome
4380: Osteoclast differentiation
4510: Focal adhesion
4512: ECM-receptor interaction
4640: Hematopoietic cell lineage
4810: Regulation of actin cytoskeleton
5410: Hypertrophic cardiomyopathy (HCM)
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)
5414: Dilated cardiomyopathy

PubMed abstracts associated with ITGB3

PMID Title Tumor Value
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no
16035619 Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. no no
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no
20798956 TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis. no no
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